Comparative cytotoxicactivity of selected Nigerian medicinal plant extracts on Ehrlich ascites carcinoma cells

Simple item page
dc.contributor.authorLawal, R.A.
dc.contributor.authorOzaslan, M.
dc.contributor.authorAdisa, R.A.
dc.contributor.authorOdesanmi, O.S.
dc.contributor.authorKaragoz, I.D.
dc.contributor.authorKilic, I.H.
dc.contributor.authorEbuehi, O.A.T.
dc.date.accessioned2020-02-19T08:46:51Z
dc.date.available2020-02-19T08:46:51Z
dc.date.issued2019
dc.descriptionStaff publicationsen_US
dc.description.abstractBackground: Nigerian medicinal plants have long been reported to manage cancer and its symptoms. Some of the frequently mentioned plants used for the treatment of cancer reported in Nigerian Ethnobotanical surveys include Securidaca longepedunculata, Tetrapleura tetraptera, Morinda lucida, Spondias mombin and Nymphaea lotus. The cytotoxicities of some of these plants have been reported in literature. However, there is no comparison of the cytotoxicities of these plants on Ehrlich ascites carcinoma (EAC) cells. This research aims to compare the in vitro cytotoxic activities of the anti-cancer plants using EAC cells. Method: Aqueous extracts of Securidaca longepedunculata, Tetrapleura tetraptera, Morinda lucida, Spondias mombin and ethanol extracts of Tetrapleura tetraptera, Spondias mombin, Nymphaea lotus were prepared. The different extracts were used to test for cytotoxicity on Ehrlich ascites carcinoma cells using the Trypan blue dye exclusion principle. Results: All extracts caused dose-dependent increase in mortality of EAC cells. IC50 values of the extract range from 11.48 for Aqueous extract of Tetrapleura tetraptera to 2691μg/ml for ethanol extract of Nymphaea lotus. Conclusion: Aqueous extract of Tetrapleura tetraptera was the most cytotoxic with an IC50 of 11.48 μg/ml compared to 5-fluorouracil with 2.88 μg/ml.en_US
dc.identifier.citationLawal, R.A., Ozaslan, M., Adisa, R.A., Odesanmi, O.S., Karagoz, I.D., Kilic, I.H., & Ebuehi, O.A.T. (2019). Comparative cytotoxicactivity of selected Nigerian medicinal plant extracts on Ehrlich ascites carcinoma cells. LASU Journal of Health Sciences, Vol.2(2).en_US
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/7706
dc.language.isoenen_US
dc.publisherLASU Journal of Health Sciencesen_US
dc.relation.ispartofseriesLASU Journal of Health Sciences;Vol.2(2)
dc.subjectSecuridaca longepedunculataen_US
dc.subjectSpondias mombinen_US
dc.subjectTetrapleura tetrapteraen_US
dc.subjectNymphaea lotusen_US
dc.subjectMorinda lucidaen_US
dc.subjectcytotoxicen_US
dc.subjectplantsen_US
dc.subjectNigeriaen_US
dc.subjectResearch Subject Categories::MEDICINE::Chemistry::Biochemistryen_US
dc.titleComparative cytotoxicactivity of selected Nigerian medicinal plant extracts on Ehrlich ascites carcinoma cellsen_US
dc.typeArticleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Ridwan et al-4-1.pdf
Size:
198.6 KB
Format:
Adobe Portable Document Format
Description:
Full Text
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Biochemistry-Scholarly Publications