Neurobehavioural and Neurotoxic Effects of L-ascorbic Acid and L-tryptophan in Lead Exposed Rats
| dc.contributor.author | Ebuehi, O.A.T. | |
| dc.contributor.author | Ayinde, O.C | |
| dc.date.accessioned | 2024-05-08T12:36:01Z | |
| dc.date.available | 2024-05-08T12:36:01Z | |
| dc.date.issued | 2012 | |
| dc.description | Scholarly article | |
| dc.description.abstract | Background: Lead is an environmental toxicant,occupational and environmental exposures remain a serious problem in developing and industrializing countries Objective: This study is designed to investigate the effects of L-ascorbic acid and L-tryptophan on the neurotoxicity and neurobehavioural alterations in lead exposed male Sprague Dawley rats. Methods: Experimental animals were exposed to oral doses of lead (Pb), L-ascorbic acid, and L-tryptophan at 75mg/kg body weight, 40mg/kg body weight, and 20mg/kg body weight respectively, while control animals received 0.90% saline solution. Oral administration spanned for four weeks after which changes in neuro-behaviour, organ weight, blood deposition of Pb, brain serotonin, tryptophan and neuronal redox status were determined. Changes in organ weight, blood lead levels, neuro-behavioural characteristics, brain serotonin and tryptophan contents, and brain redox status were determined. Results: The results indicated that Pb exposure increased blood lead, organ-weight index, and behavioural signs of anxiety and aggression. The sub-chronic exposure to Pb also decreased brain serotonin, while causing oxidative stress by decreasing reduced glutathione levels, antioxidant enzyme activity and increasing lipid peroxidation and brain protein contents. L-ascorbic acid attenuated both Pb induced neuronal oxidative stress, and abnormalities in behaviour. But L-tryptophan ameliorated Pb altered neurobehaviour with no significant effect on Pb induced oxidative stress in the brain. Co-administration of L-ascorbic acid and L-tryptophan on Pb exposed rats showed a reversal in all indices assessed towards the physiological state of control. Conclusion: This suggests that L-ascorbic and L tryptophan can be used to compliment chelating therapy in lead neurotoxicity. | |
| dc.identifier.citation | Ebuehi, O.A.T. and Ayinde, O.C (2012). Neurobehavioural and Neurotoxic Effects of L-ascorbic Acid and L-tryptophan in Lead Exposed Rats. Nigeria Qt Journal Hospital Medicine 22 (4):240-244. | |
| dc.identifier.uri | https://ir.unilag.edu.ng/handle/123456789/12870 | |
| dc.language.iso | en | |
| dc.publisher | Nigeria Qt Journal Hospital Medicine | |
| dc.relation.ispartofseries | Nigeria Qt Journal Hospital Medicine ; 22(4) | |
| dc.title | Neurobehavioural and Neurotoxic Effects of L-ascorbic Acid and L-tryptophan in Lead Exposed Rats | |
| dc.type | Article |