Serum homocysteine and disease severity in sickle cell anemia patients in Lagos

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dc.contributor.authorUche, E
dc.contributor.authorAdelekan, O
dc.contributor.authorAkinbami, A
dc.contributor.authorOsunkalu, V
dc.contributor.authorIsmail, K
dc.contributor.authorOgbenna, A.A
dc.contributor.authorBadiru, M
dc.contributor.authorDosunmu, A
dc.contributor.authorOluwole, E
dc.contributor.authorKamson, O
dc.date.accessioned2020-01-29T14:12:02Z
dc.date.available2020-01-29T14:12:02Z
dc.date.issued2019-05
dc.descriptionStaff publicationsen_US
dc.description.abstractPurpose: Hypercoagulability in sickle cell anemia (SCA) may be responsible for the increased development of vascular occlusion in certain organs as well as acute pain episodes. The causes of hypercoagulability in SCA are multifactorial and include raised homocysteine levels. This study, therefore, aimed to determine serum homocysteine levels in SCA patients in steady state and to correlate its levels with SCA disease severity. Patients and Methods: This was a cross-sectional study done among SCA patients in steady state attending the Haematology Clinic of the Lagos State University Teaching Hospital (LASUTH). Matched age and sex HbAA controls were also recruited. Serum homocysteine of each participant was done with enzyme-linked immunosorbent assay and disease severity score assessed in every SCA patient using clinical and laboratory parameters. Results: The mean value for homocysteine in the study group (SCA patients) was 19.80 ±19.75 µmol/L whilst that of the control group was 9.16±4.29 µmol/L. Thirty-nine out of 96 (46.6%) SCA patients had elevated homocysteine levels (>15 µmol/L) whilst all 96 participants in the control group had normal homocysteine levels. The difference in the means in the two groups was statistically significant with p=0.001. Majority (62.5%) of the SCA patients had a mild disease (severity score ≤3). There was a significant correlation between serum homocysteine levels and disease severity scores with p=0.04; χ2=4.04. Conclusion: Homocysteine levels were significantly higher in HbSS patients compared with matched HbAA controls and showed a positive correlation with disease severity scores in the SCA patients.en_US
dc.identifier.citationEbele, U., Adelekan, O., Akinbami, A., Osunkalu, V., Ismail, K., Ogbenna, A.A., Badiru, M., Dosunmu, A., Oluwole, E., Kamson, O. (2019). Serum homocysteine and disease severity in sickle cell anemia patients in Lagos. Journal of Blood Medicine. 10;127 -134.en_US
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/7543
dc.language.isoenen_US
dc.publisherJournal of Blood Medicine. Dove Medical Press Ltd.en_US
dc.relation.ispartofseriesJournal of Blood Medicine;Vol.10
dc.subjectSickle cell anaemiaen_US
dc.subjectdisease severityen_US
dc.subjecthomocysteineen_US
dc.subjectResearch Subject Categories::MEDICINEen_US
dc.titleSerum homocysteine and disease severity in sickle cell anemia patients in Lagosen_US
dc.typeArticleen_US
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