Prostacyclin, thromboxane and glomerular filtration rate are abnormal in sickle cell pregnancy
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Date
2017
Authors
Obilade, O.A.
Akanmu, A.S.
Broughton Pipkin, F.
Afolabi, B.B.
Journal Title
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Volume Title
Publisher
PLoS One
Abstract
Pregnancy increases the risk of morbidity and mortality in sickle cell disease. We previously showed pregnant women with sickle cell disease to have a relatively low plasma renin concentration in late pregnancy, associated with a lack of the expected plasma volume expansion. We hypothesized this to be due to increased systemic vascular resistance through an imbalance between the vasodilator prostacyclin and vasoconstrictor thromboxane, associated with decreased glomerular filtration rate (GFR).
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Citation
Obilade OA, Akanmu AS, Broughton Pipkin F, Afolabi BB. Prostacyclin, thromboxane and glomerular filtration rate are abnormal in sickle cell pregnancy. PLoS One. 2017;12(9):e0184345. doi: 10.1371/journal.pone.0184345. eCollection 2017. PubMed PMID: 28880908; PubMed Central PMCID: PMC5589233.