Prostacyclin, thromboxane and glomerular filtration rate are abnormal in sickle cell pregnancy

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dc.contributor.authorObilade, O.A.
dc.contributor.authorAkanmu, A.S.
dc.contributor.authorBroughton Pipkin, F.
dc.contributor.authorAfolabi, B.B.
dc.date.accessioned2020-09-09T14:46:37Z
dc.date.available2020-09-09T14:46:37Z
dc.date.issued2017
dc.description.abstractPregnancy increases the risk of morbidity and mortality in sickle cell disease. We previously showed pregnant women with sickle cell disease to have a relatively low plasma renin concentration in late pregnancy, associated with a lack of the expected plasma volume expansion. We hypothesized this to be due to increased systemic vascular resistance through an imbalance between the vasodilator prostacyclin and vasoconstrictor thromboxane, associated with decreased glomerular filtration rate (GFR).en_US
dc.identifier.citationObilade OA, Akanmu AS, Broughton Pipkin F, Afolabi BB. Prostacyclin, thromboxane and glomerular filtration rate are abnormal in sickle cell pregnancy. PLoS One. 2017;12(9):e0184345. doi: 10.1371/journal.pone.0184345. eCollection 2017. PubMed PMID: 28880908; PubMed Central PMCID: PMC5589233.en_US
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/8820
dc.language.isoenen_US
dc.publisherPLoS Oneen_US
dc.titleProstacyclin, thromboxane and glomerular filtration rate are abnormal in sickle cell pregnancyen_US
dc.typeArticleen_US
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