National survey found that managing childhood nephrotic syndrome in Nigeria varied widely and did not comply with the best evidence.

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dc.contributor.authorEsezobor, C.I.
dc.contributor.authorAsinobi, A.
dc.contributor.authorOkafor, H.
dc.contributor.authorAkuse, R.
dc.contributor.authorGbadegesin, R.
dc.date.accessioned2020-02-11T14:07:44Z
dc.date.available2020-02-11T14:07:44Z
dc.date.issued2018
dc.descriptionStaff publicationsen_US
dc.description.abstractAim: This study explored any variations in managing childhood nephrotic syndrome between specialist centres in Nigeria and how closely the care reflected the best available evidence. Methods: In 2016, the heads of Nigerian paediatric nephrology units were asked to complete a study questionnaire that focused on managing nephrotic syndrome. Results: Of the 31 clinicians we approached, 81% returned the completed questionnaire. The majority (64%) had received paediatric nephrology training and 40% had practised for at least 10 years. We found that 60% prescribed an initial daily prednisolone for four weeks before reducing the dose and 32% prescribed it for six weeks. However, more marked variations were observed with the total steroid duration for new-onset nephrotic syndrome, with 16%, 44% and 40% prescribing prednisolone for 8, 12 and at least 16 weeks, respectively. Similarly, 56% prescribed prednisolone for less than eight weeks before diagnosing steroid-resistant nephrotic syndrome (SRNS) and 12% rarely requested a kidney biopsy for SRNS. In addition, 32% of the respondents preferred cyclophosphamide to calcineurin inhibitors for SRNS. Conclusion: There were significant variations in the management of childhood nephrotic syndrome in Nigeria and the diagnosis and treatment of SRNS differed substantially from the best available evidence.en_US
dc.identifier.citationEsezobor, C.I.; Asinobi, A.O.; Okafor, H.U.; Akuse, R.; Gbadegesin, R. (2018). National survey found that managing childhood nephrotic syndrome in Nigeria varied widely and did not comply with the best evidence. Acta Paediatr. doi: 10.1111/apa.14409.en_US
dc.identifier.otherdoi: 10.1111/apa.14409.
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/7635
dc.language.isoenen_US
dc.publisherJohn Wiley & Sons Ltden_US
dc.subjectChildhood nephrotic syndromeen_US
dc.subjectprednisoloneen_US
dc.subjectpractice variationsen_US
dc.subjectsteroid-resistant nephrotic syndromeen_US
dc.subjectsteroid-sensitive nephrotic syndromeen_US
dc.subjectResearch Subject Categories::MEDICINEen_US
dc.titleNational survey found that managing childhood nephrotic syndrome in Nigeria varied widely and did not comply with the best evidence.en_US
dc.typeArticleen_US
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