Sublethal concentrations of triclosan and triclocarban induce histological, genotoxic and embryotoxic effects in Clarias gariepinus (Burchell, 1822)

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dc.contributor.authorJimoh, R.O
dc.contributor.authorSogbanmu, Temitope O.
dc.date.accessioned2021-04-12T09:18:42Z
dc.date.available2021-04-12T09:18:42Z
dc.date.issued2021-03
dc.descriptionScholarly articlesen_US
dc.description.abstractAntimicrobial additives in personal care products (PCPs) such as triclosan (TCS) and triclocarban (TCC) are of environmental concern due to their potential toxicity in non-target aquatic organisms. In this study, the histological, genotoxic (micronucleus assay), and embryotoxic effects of sublethal and environmentally relevant concentrations of TCS and TCC were evaluated in Clarias gariepinus (the African sharptooth catfish) over a period of 28 days. The 96 hLC50 values of TCS and TCC against fingerlings of C. gariepinus were 16.04 mg/L and 41.57 mg/L respectively. The 24 hLC50 and 26 hEC50 (non-hatching) values for C. gariepinus embryos were 16.48 mg/L and 11.08 mg/L for TCS and 46.08 mg/L and 41.93 mg/L for TCC respectively. TCS was ×3 to ×4 more toxic to C. gariepinus fingerlings and embryos than TCC. Gill histological alterations ranged from mild to severe lamellar necrosis in the exposed fishes with Gill Alteration Index (GAI) of 1.60 on day 14 and 3.20 on day 28. There were significant dose-dependent increases (p < 0.05) in micronuclei and binucleated cells in the erythrocytes of exposed fishes compared to control. Embryotoxic effects assessed from 0 to 72 h post fertilization showed significant decreases (p < 0.05) in hatching success and number of heartbeats per minute, and significant increase (p < 0.05) in percentage abnormalities in the exposed embryos compared to control. The study demonstrates the need for regulatory measures and monitoring of the use of TCS and TCC in PCPs in order to mitigate potential adverse effects to non-target aquatic organisms. This will support the United Nations Sustainable Development Goal 14 on sustaining life below water.en_US
dc.identifier.citationJimoh, R. O. and Sogbanmu, T. O. (2021). Sublethal concentrations of triclosan and triclocarban induce histological, genotoxic and embryotoxic effects in Clarias gariepinus (Burchell, 1822). Environmental Science and Pollution Researchen_US
dc.identifier.issn1614-7499
dc.identifier.otherhttps://doi.org/10.1007/s11356-021-12820-1
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/9280
dc.language.isoenen_US
dc.publisherSpringer Natureen_US
dc.subjectPersonal care products (PCPs)en_US
dc.subjectMicronucleien_US
dc.subjectCatfishen_US
dc.subjectEmbryotoxicen_US
dc.subjectHistological alterationen_US
dc.subjectSublethal concentrationsen_US
dc.subjectResearch Subject Categories::NATURAL SCIENCESen_US
dc.titleSublethal concentrations of triclosan and triclocarban induce histological, genotoxic and embryotoxic effects in Clarias gariepinus (Burchell, 1822)en_US
dc.typeArticleen_US
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