Department of Anatomic and Molecular Pathology

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Browsing Department of Anatomic and Molecular Pathology by Author "Abdul-Kareem, FB"

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  • Item
    Open Access
    EFFECT OF BRIDELIA FERRUGUBEA STEM BARK ON BLOOD CHEMISTRY AND HISTOLOGY OF SOME ORGANS IN RATS
    (Nigerian Journal of Natural Products and Medicine, 1998) Ofogba, CJ; Agbomo, FU; Abdul-Kareem, FB; Abaelu, AM; Alatishe, K
    Aqueous extract of Bridelia ferruginea stem bark caused significant increases in serum K+, creatinine, total bilirubin, GOT, GPT, HDL, Alkaline phosphate, BUN (p<0.001) and decreases in serum Na+, Cl-, CO2), cholesterol, glucose, Ca2+ (p<0.01,0.001) in rats. No changes were observed in serum triglyceride, uric acid, phosphate and total protein levels when compared with the control. The increase in some if these parameter was detected by means of PAS staining. The heart and lungs also showed adverse effects.
  • Item
    Open Access
    Prognostic factors in the management outcome of carcinoma of the larynx in Lagos.
    (Nigerian Postgraduate Medical Journal, 2003) Somefun, OA; Nwawolo, CC; Okeowo, PA; Alabi, SB; Abdul-Kareem, FB; Banjo, AA; Elesha, SO
    This is a retrospective analysis on the prognostic factors in the management outcome of clinically and histologically diagnosed carcinoma of larynx seen in Lagos University Teaching Hospital between 1996-1999. Various prognostic factors have been documented as determinants on the probable outcome of carcinoma of the larynx, such as duration of symptoms, smoking, medical status of the patient, degree of differentiation, size and site of tumour and presence of cervical lymph node. Thirty-six patients between 1996-1999 were reviewed, with a male to female ratio of 11:1, and peak age group of occurrence in 50-59 years, majority (86.12%) of which were non-smokers who presented in varied degrees of airway obstruction necessitating pre-treatment tracheostomy in 70% of the patients with more than 50% presenting within 3-6 months of onset of initial symptom. The tumours were staged clinically and histology revealed well differentiated T3 glottic tumour without any clinically palpable neck node in more than 50% of the patients which should predict a better outcome. But the interplay of many prognostic variables like pre-treatment tracheostomy and its attendant complications, supposed biological aggressive tumour in a non-smoker, coupled with treatment biased by patients, high costs of treatment, logistics and poor follow up compliance, resulted in poor outcome of our management.