Department of Anatomic and Molecular Pathology

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    Open Access
    Hepatic neoplasms in Lagos -a 10year review of surgical biopsies
    (Nigerian Postgraduate Mededical Journal, 1993) Abdulkareem, FB; Banjo, AAF; Elesha, SO
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    Open Access
    Rising incidence of cerebral malaria in Lagos, Nigeria: a postmoterm study.
    (East African Medical Journal, 1993) Elesha, S O; Adepoju, FB; Banjo, AA
    One hundred and forty seven cases of acute malaria were diagnosed at autopsy between 1988 and 1991 at the Lagos University Teaching Hospital (LUTH). In 67 (46.5%) cases death was attributed to cerebral malaria (CM). There was a gradual increase in the incidence of CM during the period under review. Both sexes were affected equally but more children than adults succumbed. The highest death rate was recorded in the age group 1-5 years with a peak in the 2nd and 3rd year. There were seven adults out of which one was intenerant white lady. Only one of the six adult Nigerians had travelled outside Africa and stayed away for about four years. The commonest presenting symptoms were: fever only, fever with convulsions and/or coma and fever with gastrointestinal symptoms such as vomiting and diarrhoea. The majority of the adults were comatose (five out of seven) without fever on admission. A review of the English literature on the diagnosis, pathogenesis and management of CM is also presented. The possible reasons of the rising incidence of CM in a holoendemic region such as Nigeria are discussed.
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    Open Access
    Adhesion molecules and rejection of renal allografts
    (Kidney international, 1997) Solez, K; Racusen, LC; Abdulkareem, FB; Kemeny, E; Willebrand, EV; Truong, L D
    Adhesion molecules and rejection of renal allografts. Despite an increasing amount of immunohistochemical and molecular biology data relating to the pathogenesis of kidney transplant rejection, the pathological diagnosis of this condition still rests on routine light microscopy. The detection of changes in expression and distribution of adhesion molecules in renal allograft biopsies may open a new era of increased accuracy of rejection diagnosis. Of the various adhesion molecule reactivities, peritubular capillary VCAM-1 staining appears to be the most specific rinding for chronic rejection. This same staining reaction is seen in acute rejection, but may have less specificity in that setting.
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    Open Access
    EFFECT OF BRIDELIA FERRUGUBEA STEM BARK ON BLOOD CHEMISTRY AND HISTOLOGY OF SOME ORGANS IN RATS
    (Nigerian Journal of Natural Products and Medicine, 1998) Ofogba, CJ; Agbomo, FU; Abdul-Kareem, FB; Abaelu, AM; Alatishe, K
    Aqueous extract of Bridelia ferruginea stem bark caused significant increases in serum K+, creatinine, total bilirubin, GOT, GPT, HDL, Alkaline phosphate, BUN (p<0.001) and decreases in serum Na+, Cl-, CO2), cholesterol, glucose, Ca2+ (p<0.01,0.001) in rats. No changes were observed in serum triglyceride, uric acid, phosphate and total protein levels when compared with the control. The increase in some if these parameter was detected by means of PAS staining. The heart and lungs also showed adverse effects.
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    Open Access
    Recurrence of anti-GBM Antibody Disease Twelve Years After Transplantation Associated With De Novo IgA Nephropathy
    (Clinical nephrology, 1998) Abdulkareem, FB; Trpkov, K; Jim, K; Solez, K
    A patient developed recurrent anti-glomerular basement membrane (GBM) antibody (ab) disease after twelve years of an uneventful posttransplant course, clinically accompanied by rapidly rising creatinine. He additionally exhibited coexisting IgA nephropathy at the time of the reappearing anti-GBM disease. Both linear IgG and mesangial IgA were detected by immunofluorescence, and electron microscopy demonstrated mesangial immune complex deposits. To our knowledge, the association of anti-GBM ab disease and IgA nephropathy has not been reported previously.
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    Open Access
    Childhood Renal Neoplasms in Lagos Nigera- A 28 Year Review
    (Nigerian Quarterly Journal of Hospital Medicine, 1999) Elesha, SO; Abdulkareem, FB
    Out of 131 nephretomies received at the Morbid Anatomy Department of the Lagos University Teaching Hospital, there were 63 cases of childhood renal cancer representing 48% of total renal neoplasm seen over a period of 1970-1997. The ages range from 21/2 months - 11 years; over 75% of the cases were found under 5 years with only 3.2% occurring above 10 years. The male female ratio is 1:1. Of the cancers, there were 42 cases of classical nephroblastoma and 10 cases of the blastema type of nephroblastoma. We had 7 cases of purely sarcomatous nephroblastoma one of which is a rhabdomyosarcoma and the remaining 6 were undifferentiated sarcoma. There was one case of anaplastic carcinoma. Also seen was a case of mesoblastic nephroma in a 21/2 months male infant. In this study, neither benign neoplasm nor congenital tumour (angiomyolipoma) was encountered, in all cases, there was no age nor sex disparity. Most of the patients presented with abdominal mass with a unilaterally enlarged kidney, abdominal pain, haematuria and weight loss. All of them had nephrectomy as initial treatment followed by radiotherapy and chemotherapy.
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    Open Access
    The Association Between Cancer Of The Breast And The Abo And Rhesus D Antigen Phenotypes In Lagos, Nigeria; A Case-Control Study
    (Nigerian Journal of Clinical Practice, 2002) Akammu, AS; Ajekighe, AT; Durusinmi-Etti, FAA; Akinsete, L; Emuveyan, EE; Abdul-Kaareem, FB; Ugwaudu, CS; Dawotola, DA
    Objective: To determine whether inheritance of ABO and Rhesus D antigen phenotypes constitute a risk factor for development of cancer of the breast. Design: A case-control study. Setting: Patients with histologically diagnosed cancer of the breast referred to Radiotherapy department of the Lagos University Teaching Hospital over a six-month period were included in the study (cases). Healthy blood donors at the Donors Clinic of the hospital over the same period of time were also studied (Control A). Women attending family planning clinic were also studied and referred to as Control B. Materials & Methods: Routine ABO and Rhesus D-phenotyping was carried out on washed red cell specimens of all cases and controls. The odds that cancer of the breast was due to presence of a given phenotype were determined (odds of cases). The odds that the given phenotype is present in the normal population without cancer of breast was also determined (odds of control). The Odds Ratio (OR) given by odds of cases/odds of control served as an estimate of the Relative Risk (RR) that the given phenotype is associated with the cancer of the breast. Result: 107 cases, 2.243 controls A and 122 controls B were studied. Of the cases, only one was a male, the others were females. Their ages ranged between 24 and 85 years with a median of 45 years. The controls A were all males with ages ranging between 22 and 55 years. Controls B were females with ages ranging between 21 and 47 years. A,B,O, AB, Rhesus D positive and Rhesus D negative phenotype distribution amongst the cases, controls. A and B were 28,22,54,3,97 and 10,589,440,1143,71,2142 and 101,27,25,70,.0,117 and 5 respectively. Of all the phenotypes, only the inheritance of Rhesus D antigen gave a relative risk (RR) significantly below unity. RR=0.45. Standard error=0.76 and p. <0.05 when cases were compared with controls A. RR=0.41,SE=0.56 and P>0.05 when cases were compared with control B. Conclusion: Negative association was established between inheritance of Rhesus D antigen and the development of cancer of the breast. Rhesus D antigen phenotype may be protective against cancer of the breast.
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    Open Access
    Prognostic Factors in the Management Outcome of Carcinoma of the Larynx in Lagos
    (Nigerian Postgraduate Medical Journal, 2003) Somefun, O A; Nwawolo, C C; Okeowo, P A; Alabi, S B; AbdulKareem, FB; Banjo, A A; Elesha, S O
    This is a retrospective analysis on the prognostic factors in the management outcome of clinically and histologically diagnosed carcinoma of larynx seen in Lagos University Teaching Hospital between 1996-1999. Various prognostic factors have been documented as determinants on the probable outcome of carcinoma of the larynx, such as duration of symptoms, smoking, medical status of the patient, degree of differentiation, size and site of tumour and presence of cervical lymph node. Thirty-six patients between 1996-1999 were reviewed, with a male to female ratio of 11:1, and peak age group of occurrence in 50-59 years, majority (86.12%) of which were non-smokers who presented in varied degrees of airway obstruction necessitating pre-treatment tracheostomy in 70% of the patients with more than 50% presenting within 3-6 months of onset of initial symptom. The tumours were staged clinically and histology revealed well differentiated T3 glottic tumour without any clinically palpable neck node in more than 50% of the patients which should predict a better outcome. But the interplay of many prognostic variables like pre-treatment tracheostomy and its attendant complications, supposed biological aggressive tumour in a non-smoker, coupled with treatment biased by patients, high costs of treatment, logistics and poor follow up compliance, resulted in poor outcome of our management.
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    Open Access
    Cervical Cytology in an Urban Population in Lagos, Nigeria
    (Journal of Obstetrics and Gynaecology, 2003) Anorlu, R I; AbdulKareem, FB; Abudu, O O; Oyekan, T O
    Eight hundred and eighty-four consecutive women had cervical smears in a clinic in Lagos, Nigeria between September 1998 and 31 August 1999. Mean age was 36.6 - 11.6 years (range 16-81 years); 93.7% were first-time screening. Three hundred and twenty-five (36.5%) smears were normal, inflammatory smears 52.7%, mild dyskaryosis 2.4%, moderate dyskaryosis 1.5%, severe dyskaryosis 0.3% and probable malignancy (malignant cells) 0.8%. Abnormal smears were higher in symptomatic cases compared with asymptomatic cases (chi2=15.3, P< 0.01); 6.1% and 2.1% of symptomatic cases had dyskaryosis and carcinoma, respectively, compared with 3.4% and 0.1% for asymptomatic cases. In postcoital bleeding 9.3% and 1.9% had dyskaryosis and carcinoma, respectively. Fifty-six of 62 cases of cervical erosion had abnormal smears. In postmenopausal bleeding 13.0% and 4.3% had dyskaryosis and carcinoma, respectively. Prevalence of abnormal cervical smears is high in women who have genital tract disease. In places with no national screening programmes every effort should be made to screen such women.
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    Open Access
    Prognostic factors in the management outcome of carcinoma of the larynx in Lagos.
    (Nigerian Postgraduate Medical Journal, 2003) Somefun, OA; Nwawolo, CC; Okeowo, PA; Alabi, SB; Abdul-Kareem, FB; Banjo, AA; Elesha, SO
    This is a retrospective analysis on the prognostic factors in the management outcome of clinically and histologically diagnosed carcinoma of larynx seen in Lagos University Teaching Hospital between 1996-1999. Various prognostic factors have been documented as determinants on the probable outcome of carcinoma of the larynx, such as duration of symptoms, smoking, medical status of the patient, degree of differentiation, size and site of tumour and presence of cervical lymph node. Thirty-six patients between 1996-1999 were reviewed, with a male to female ratio of 11:1, and peak age group of occurrence in 50-59 years, majority (86.12%) of which were non-smokers who presented in varied degrees of airway obstruction necessitating pre-treatment tracheostomy in 70% of the patients with more than 50% presenting within 3-6 months of onset of initial symptom. The tumours were staged clinically and histology revealed well differentiated T3 glottic tumour without any clinically palpable neck node in more than 50% of the patients which should predict a better outcome. But the interplay of many prognostic variables like pre-treatment tracheostomy and its attendant complications, supposed biological aggressive tumour in a non-smoker, coupled with treatment biased by patients, high costs of treatment, logistics and poor follow up compliance, resulted in poor outcome of our management.
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    Open Access
    Wilms' tumour – A 5-Year Review of Cases seen in Lagos University Teaching Hospital
    (Journal of Clinical Sciences, 2005) Akinsulie, AO; Temiye, EO; Odelola, MA; Bode, CO; Abdulkareem, FB
    Objective: The study was carried out to review the clinical stage at which cases of Wilms' tumour in children were admitted in Lagos University Teaching Hospital, Lagos, Nigeria, the pathology of the disease, the management employed, the outcome and the effectiveness of the out-patient clinic follow up. Method: The case-notes of all patients managed for Wilms' tumour in the department of Paediatrics, Lagos University Teaching Hospital were reviewed over a period of five years, 1999 to 2003, in a retrospective study. Results: A total of 35 cases were admitted during the study period; comprising 20 males and 15 females. Nineteen of them had nephrectomy, chemotherapy and radiotherapy. Sixteen of these 19 patients were in stages III to V. One patient died three days after nephrectomy. Two out of the patients who had no surgery had chemotherapy and radiotherapy but died before surgery could be performed. The remaining 14 patients had some courses of chemotherapy and radiotherapy but were later discharged against medical advice; also 87.5% of all the cases discharged were lost to follow up. Conclusion: Majority of cases of Wilms' tumour managed in Lagos University Teaching Hospital presented late. There was a high rate of discharge against medical advice. Also there was a high rate of default at the follow-up clinic.
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    Open Access
    Histological Review of Thyroid Lesions: A 13-year Retrospective Study (1989-2001)
    (Nigerian Postgraduate Medical Journal, 2005) Abdulkareem, FB; Banjo, A A; Elesha, S O
    Objective: We present a 13-years retrospective histological study of 444 thyroidectomies received between 1989 and 2001 at the Morbid Anatomy department of the Lagos University Teaching Hospital, Nigeria. The aim of the study is to update the available literature on the frequencies of the common thyroid lesions as well as compare with previous studies. Materials and methods: The materials for this study consist of slides and paraffin embedded blocks of all thyroidectomies received from within and outside the teaching hospital. The clinical data such as the age, sex, and clinical summary were extracted from the request forms. Results: The male: female ratio is 1: 7. The most common entity was goiter (74%); most of which occurred in the age group 30-39 yrs. Thyroid adenomas (majority; follicular), constituted 10%. There were 29 cases of thyroid carcinoma accounting for 7% of all lesions and occurring more in females than males (17:12). Histologically, follicular carcinoma predominated (48.3%), followed by papillary carcinoma (34.5%) and medullary carcinoma (13.8%). Thyroiditis was uncommon (only 2%). Conclusion: Goiter, adenoma and carcinoma remain the commonest pathologic entities of the thyroid gland in Lagos. The age and sex incidences as well as the histological characteristics concur with reports from other parts of Africa and Nigeria. However, unlike many of the Nigerian series except the latest from Ibadan, 4 cases of medullary carcinoma were encountered in this study. The frequencies of toxic hyperplasia and thyroiditis are also lower than those recorded in previous studies.
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    Open Access
    Conjunctival Melanoma in a 55 Year Old Male Nigerian: A Case Report
    (Nigerian Postgraduate Medical Journal, 2006) Anonubi, C C; Akinsola, F B; Abdulkareem, FB; Aribaba, O T; Anyiam, D C D; Daramola, A O; Banjo, A A F
    Background: Conjunctival melanoma is a rare occurrence in the Negroid race. Purpose: To report a case of a 55 year old security man with right conjunctival melanoma. Method: A 55 old man was operated on to remove a pigmented right bulbar conjuctival growth. The specimen was submitted to Lagos University Teaching Hospital Lagos and Harold Wood Hospital England for histopathologic examination and confirmation. Results: Surgery was successful and histopathologic and immunohistochemical studies confirmed a diagnosis of a nodular malignant melanoma. Conclusion: The need for the provision of definitive investigative tool (immunohistochemical studies) to facilitate definitive diagnosis and management of such cases in some recognised centres in Nigeria cannot be overemphasised.
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    Open Access
    Histopathological study of Liver diseases in LUTH
    (Nigerian Postgraduate Medical Journal, 2006) Abdulkareem, FB; Banjo, AAF; Elesha, SO; Daramola, AO
    Abstract Objective: We present a retrospective histopathological study of 345 liver biopsies over a 12-year period. The study sought to record the frequencies of the range of histopathological changes observed in liver biopsy specimens. Materials and methods: the materials consisted of slides and paraffin embedded blocks of all liver biopsy specimens received from within and outside the hospital. The clinical data such as the age, sex, and clinical summary were extracted from the request forms. Results: there were 222 males and 123 females; M: F=1.8:1; peak age incidence of 41-50 years. The three common histopathological diagnoses were hepatocellular carcinoma-33%, chronic hepatitis-17.7%, and liver cirrhosis-17.7%. Thirty per cent of hepatocellular carcinoma was post-cirrhotic. The peak age incidence of chronic hepatitis precedes that of liver cirrhosis and hepatocellular carcinoma by one decade. Conclusion: the common forms of liver disease diagnosed histologically are hepatocellular carcinoma, chronic hepatitis and liver cirrhosis. The age and sex distribution are similar to those already established in the African literature.
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    Open Access
    Fine Needle Aspiration Cytology of Bone Tumours--The Experience From the National Orthopaedic and Lagos University Teaching Hospitals, Lagos, Nigeria
    (Cytojournal, 2006) Nnodu, OE; Giwa, S O; Eyesan, S U; Abdulkareem, FB
    Background: Due to difficulty in confirming clinical suspicions of malignancy in patients presenting with bone tumours, the cost of surgical biopsies where hospital charges are borne almost entirely by patients, competition with bone setters and healing homes with high rate of loss to follow up; we set out to find if sufficient material could be obtained to arrive at reliable tissue diagnosis in patients with clinical and radiological evidence of bone tumours in our hospitals. Methods: After initial clinical and plain radiographic examinations, patients were sent for fine needle aspirations. Aspirations were carried out with size 23G needles of varying lengths with 10 ml syringes in a syringe holder (CAMECO, Sebre Medical, Vellinge, Sweden). The aspirates were air dried, stained by the MGG method and examined microscopically. Histology was performed on patients who had subsequent surgical biopsy. These were then correlated with the cytology reports. Results: Out of 96 patients evaluated, [57 males, 39 females, Mean age 31.52 years, Age Range 4-76 years,] material sufficient for diagnosis was obtained in 90 patients. Cytological diagnosis of benign lesions was made in 40 patients and malignant in 47. Of these, 27 were metastases, osteogenic sarcoma 16, giant cell tumour 19, infection 11. Histology was obtained in 41 patients. Correct diagnosis of benignity was made in 17 out of 18 cases, malignancy in 21 out of 22 cases. One non-diagnostic case was malignant. The accuracy of specific cytological diagnosis was 36/41 (87.8%) and incorrect in 5/41 (12.2%). Conclusion: We conclude that FNAC can be useful in the pre-operative assessment of bone tumours especially where other diagnostic modalities are unavailable.
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    Open Access
    Adult Lymphomas in Lagos Nigeria: A Fourteen Year Study
    (Nigerian Quarterly Hospital of Medicine, 2007) Anunobi, C C; Banjo, A A F; Abdulkareem, FB; Daramola, A O; Akinde, R O; Abudu, E K
    Objective: we present a 14 year retrospective histopathological study of 92 cases of adult lymphomas in Lagos. The aim is to document the histologic types, age and sex distribution. Materials and method: The materials consisted of slides and paraffin embedded blocks of all cases of lymphoma in adults above the age of 16 years seen between 1991 and 2004 at the Morbid Anatomy Department of Lagos University Teaching Hospital Idi-Araba Lagos. Results: Of ninety two cases of lymphoma studied, male and female patients accounted for 59(64%) and 33(36%) cases respectively, giving a M: F ratio of 1.8:1. The most frequently biopsied site is the cervical lymph node. Non-Hodgkin's lymphoma (NHL) which accounted for 60 cases occurred most frequently in the 46-55 years age group and gives a male: female ratio of 2:1. Intermediate grade, high grade and low grade variants of NHLs accounted for 39%, 34% and 27% respectively. Hodgkin's lymphoma mostly affected patients of younger age group, 25-35 years with a M:F ratio of 1.7:1. Mixed cellularity 17 (55%) was the commonest subtype of Hodgkin's lymphoma. Conclusion: Non-Hodgkin's lymphoma is commoner than Hodgkin's lymphoma. The age and sex distribution agrees with reports from other parts of Nigeria and Africa with minimal variations.
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    Open Access
    Management of Giant Cell Tumour: A Nigerian Experience
    (Nigerian Journal of Surgical Sciences, 2007) Eyesan, S U; Obalum, D C; Nnodu, O E; Abdulkareem, F B; Ladejobi, A O
    Giant cell tumours (GCT) are the commonest bone tumours worldwide. It is rarely malignant but when it does it progresses to fibrosarcoma with high mortality. Otherwise it causes poor cosmesis, disability and pathological fractures. A total of 19 cases of histologically established Giant cell tumour of the bone were reviewed prospectively in a 5 year study. 14 cases were benign, 4 malignant and one was a malignant transformation. Lesions around the knee accounted for 42.2% of the cases, but the radius was the commonest single bone affected with 26.3%. Eleven patients had curettage, five of them had autogenous bone grafting while the remaining six had bone grafting and plate augmentation. One patient had fore-quarter amputation while seven had tumour resection. There was no recurrence recorded among those that had currretage and autogenous bone grafting. 33% of those that had curettage and bone cementing as well as 16.6% of those that had resection presented with recurrence. One patient died within 3 months of surgery due to metastasis to the lungs, liver and spleen. Mean follow up was 9.2 months (range of 2 to 60 months). With early presentation, curretage and bone grafting is often effective; late presentation however has an increased risk of recurrence due to soft tissue involvement, dearth of investigative tools and financial constraints.
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    Open Access
    Extremity Soft Tissue Sarcoma: A Review of 19 Cases.
    (Nigerian Journal of Orthopaedics and Trauma, 2007) Eyesan, S U; Idowu, O K; Chira, M K; Nnodu, O E; Abdulkareem, F B; Ketiku, K K
    Background: Although soft tissue sarcoma is a rare tumour, it accounts for a significant proportion of malignancies seen in many orthopaedic practices. The objectives of this study are to evaluate the pattern of presentation of extremity soft tissue sarcoma and the treatment outcome in our patients. Method: This is a 3 year prospective study in patients presenting with extremity soft tissue sarcoma at the oncology unit of the National Orthopedic Hospital Lagos. Data, such as age, sex, presenting complaints, anatomic location of lesions, histologic type of tumour, and treatment outcome were retrieved from prepared proforma. The average follow up period was 22.8 months. Results: Nineteen patients were studied. The age range of the patients was 3 to 69 years, male to female ratio of 1.7: 1. Most tumours were located in the thigh and the leg, and malignant fibrous histiocytoma was the most common histologic diagnosis. Whilst all the patients presented with stages II and III diseases, limb salvage was only possible in 52.6% of these patients. Surgery was always combined with adjuvant radiotherapy. A survival rate of 69% and a recurrence rate of 16% were recorded over the period of the study. Conclusion: Delayed presentation limited the scope of limb salvage surgery in centers such as ours, but appropriate tumour excision and adjuvant radiotherapy remains the mainstay of the management.
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    Open Access
    Surgery of Parotid Gland Tumours in Lagos: A 12 Year Review
    (Nigerian Postgraduate Medical Journal, 2007) Somefun, O A; Oyeneyin, J O; Abdulkareem, F B; da Lilly-Tariah, O B; Nimkur, L T; Esan, O O
    Background/aim: Tumours of the parotid gland are not common. Parotid tumours can pose a challenge both in diagnosis and treatment. Various factors contribute to the management difficulties of parotid tumours for the Head neck surgeon. The aim of the study is to determine the presentation and management of parotid tumours requiring surgery at the Burns and Plastic and Otolaryngology (ORL) units of the hospital. Materials and methods: This is a retrospective study carried out at the Lagos University Teaching Hospital from January 1994- December 2005. The medical case notes were reviewed for information on age, sex, clinical presentation, surgical management, histological diagnosis and outcome. Results: A total of 58 patients with parotid tumours were seen with ages ranging from 25-65 years. Male to Female ratio was 1.4:1. Forty-two (72.4%) presented with firm preauricular swelling, 1.7% as dumb bell tumour and post surgical recurrence tumour respectively, 6.8% as tail of parotid tumour and 3.5% as bilateral disease. 93.13% had superficial parotidectomy. Histological diagnosis confirmed 65.5% as pleomorphic adenoma, 20.72% as carcinomas of which adenoidcystic and mucoepidermoid tumours were the commonest,3.45% as lymphoma and 1.7% as Sjogrens syndrome, oxyphil and Warthins tumour respectively. Immediate post surgical facial nerve palsy was seen in 69% and recovery was seen in 62% within 3-9months. Post surgical radiotherapy was given to 8.6%. Conclusion: The commonest parotid salivary gland tumour requiring surgery is pleomorphic adenoma, presenting as a pre-auricular mass and the commonest post- surgical complication was facial nerve palsy involving the mandibular branch. A good knowledge of the surgical anatomy of the gland, clinical behaviour and biologic nature of the tumours will ensure better surgical management.
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    Open Access
    Pathological Study of Bone Tumours at the National Orthopaedic Hospital, Lagos, Nigeria
    (West African Journal Of Medicine, 2007) Abdulkareem, F B; Eyesan, S U; Akinde, O R; Ezembakwe, M E; Nnodu, O E
    Background: Although primary bone tumours are relatively uncommon, they constitute the most important tumours in patients under 20 years. Objective: To update the literature on the relative frequency and clinico-pathologic characteristics of bone tumours in this environment. Materials and methods: The clinical and histopathological records of patients presenting with diagnosis of bone tumours between 1999 and 2004 and managed at the National Orthopaedic Hospital, Igbobi, (NOHI) Lagos, Nigeria were review and where necessary, new ones were prepared from the paraffin blocks and stained with routine haematoxylin and eosin stain. The clinical data such as the age, sex, presenting signs and symptoms, site distribution of lesions, radiological finding as well as the record of other investigation and management were extracted from the clinical case notes of patients. Results: Seventy-seven cases were recorded; 61 (79.2%) benign and 16 (15.6%) malignant. The male:female ratio for all tumours was 2:1. The commonest benign bone tumours were osteochondroma and giant cell tumour accounting for 52 (67%) of all cases with > 60% in males. The most common primary malignant bone tumour was osteosarcoma, all in males. The peak incidence was in the second and third decades and commonest sites were the distal femur and proximal tibia. Four (5.2%) cases of metastatic bone tumours located commonly in the proximal femur and humerus were also recorded. Conclusion: Osteochondroma and giant cell tumours are the commonest benign tumours while osteosarcoma is the most common primary bone tumour all occurring in the first two decades of life. The age and sex distribution and morphology are similar to those already established in the African and international literature.