Department of Anatomic and Molecular Pathology

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Browsing Department of Anatomic and Molecular Pathology by Author "Abudu, E K"

Now showing 1 - 4 of 4
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    Open Access
    Adult Lymphomas in Lagos Nigeria: A Fourteen Year Study
    (Nigerian Quarterly Hospital of Medicine, 2007) Anunobi, C C; Banjo, A A F; Abdulkareem, FB; Daramola, A O; Akinde, R O; Abudu, E K
    Objective: we present a 14 year retrospective histopathological study of 92 cases of adult lymphomas in Lagos. The aim is to document the histologic types, age and sex distribution. Materials and method: The materials consisted of slides and paraffin embedded blocks of all cases of lymphoma in adults above the age of 16 years seen between 1991 and 2004 at the Morbid Anatomy Department of Lagos University Teaching Hospital Idi-Araba Lagos. Results: Of ninety two cases of lymphoma studied, male and female patients accounted for 59(64%) and 33(36%) cases respectively, giving a M: F ratio of 1.8:1. The most frequently biopsied site is the cervical lymph node. Non-Hodgkin's lymphoma (NHL) which accounted for 60 cases occurred most frequently in the 46-55 years age group and gives a male: female ratio of 2:1. Intermediate grade, high grade and low grade variants of NHLs accounted for 39%, 34% and 27% respectively. Hodgkin's lymphoma mostly affected patients of younger age group, 25-35 years with a M:F ratio of 1.7:1. Mixed cellularity 17 (55%) was the commonest subtype of Hodgkin's lymphoma. Conclusion: Non-Hodgkin's lymphoma is commoner than Hodgkin's lymphoma. The age and sex distribution agrees with reports from other parts of Nigeria and Africa with minimal variations.
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    Open Access
    Endometrial Carcinoma Following Treatment for Breast Carcinoma in a Nigerian Female. A Case Report and Review of the Literature
    (Nigerian Postgraduate Medical Journal, 2017) AbdulKareem, F B; Adefuye, P O; Musa, O; Abudu, E K; Agboola, A O J; Banjo, A A F
    Tamoxifen is the primary hormonal therapy for breast cancer as well as its chemoprevention. It is used in the management of breast cancer because of its anti oestrogenic effect. It is however an agonist on the endometrium with undesirable effects of endometrial proliferation with the risk of endometrial hyperplasia and carcinoma. Several authors have reported cases of endometrial hyperplasia and carcinoma following tamoxifen therapy for breast carcinoma. No such report has been made from Nigeria . This paper presents the first case of endometrial carcinoma following tamoxifen therapy for breast carcinoma in a 52 year old Nigerian female. It also highlights the recommended guidelines for the follow up of women with breast cancer on tamoxifen therapy.
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    Open Access
    Histopathological characteristics of breast carcinomas at the Olabisi Onabanjo University Teaching Hospital, Sagamu Ogun State, Nigeria
    (Nigerian Journal of Health and Biomedical Sciences, 2008) Banjo, A A; Musa, O; Tade, A O; Ayoade, BA; Daramola, A O; Abdulkareem, F B; Abudu, E K; Agboola, AJ; Igbokwe, U
    This study examines the pathological grade as well as the estrogen progesterone receptor (ERPR) status in breast cancer materials from Olabisi Onabanjo University Teaching Hospital, Sagamu, Nigeria. All histopathologically diagnosed tissue samples from the department of Histopathology of the Olabisi Onabanjo University Teaching Hospital, Sagamu seen from January 2003 to December 2004 were examined and graded using the Elston and Ellis Modification of the Scarff-Bloom –Richardson grading system1 and stained for their estrogen/progesterone receptor status. Forty- seven cases of breast carcinoma were seen during the period under study. Of these, 44(93.7%) were invasive ductal carcinoma, with majority being poorly differentiated. Their ages ranged from 25-75 years with majority in the age group 40-59years. The mean age was 47.3 years. Of the 27 cases that had their ERPR status analyzed, 21 cases (77.8%) were ERPR negative, while only 3 (11.1%) were ERPR positive. This study shows that there is a predominance of high grade invasive ductal carcinomas that are likely to be ERPR negative. These features suggest a biologically aggressive form of breast cancer in Nigeria with the possibility of poor response to hormonal therapy.
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    Open Access
    Review of the Histopathologic Patterns of Superficial Lymph Node Diseases, in Lagos (1991-2004)
    (Nigerian Postgraduate Medical Journal, 2008) Anunobi, C C; Banjo, A A F; Abdulkareem, F B; Daramola, A O; Abudu, E K
    Objective: This is a 14-year retrospective histopathologic study of 720 lymph node biopsies. The aim is to document the causes of lymphadenopathy, the age and sex distribution in Lagos. Materials and methods: The materials consisted of slides and paraffin embedded blocks of all lymph node biopsy specimens received from within and outside Lagos University Teaching Hospital, Lagos. Results: A total of 720 biopsies from 276 males and 444 females were analysed. Chronic non specific lymphadenitis 245 (34%), tuberculosis 125 (17.4%), metastatic lymph node lesions 242 (33.6%), and lymphomas 102(14.2%) were the common causes of lymph node enlargement. The commonest lymph node group affected was the cervical 283 (39.3%). Conclusion: Malignancy (47.8%) is the most common cause of superficial lymphadenopathy in Lagos metropolis. The age, sex and site prevalence agree with reports from other parts of Nigeria and Africa with minimal variations.