Biochemistry-Scholarly Publications

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Browsing Biochemistry-Scholarly Publications by Author "Adeboyejo, Folasade O."

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  • Item
    Open Access
    Modulatory effect of fibre-enriched cake on alloxan-induced diabetic toxicity in rat brain tissues
    (Elsevier, 2014-07-24) Erukainure, Ochuko L.; Ebuehi, Osaretin A.T.; Adeboyejo, Folasade O.; Aliyu, Muhammad; Elemo, Gloria N.
    tDiabetes is a metabolic disorder characterized by hyperglycaemia and it is fast becoming ascourge in sub-Saharan Africa. The nutritional properties of developed fibre-enriched cakeand its protective potential against diabetic induced neurotoxicity in rats were investigated.Fibre-enriched cake was developed from selected fruits and analysed for its nutritional andsensory attributes. Rats were induced with diabetes by a single intraperitoneal injectionof alloxan and treated with the formulated cake. After 14 days treatment, the rats weresacrificed by cervical dislocation. Their brain tissues were accessed for reduced glutathione(GSH), catalase, superoxide dismutase (SOD) activities, protein content and lipid peroxida-tion as well as lipid profiles which cover for total cholesterol, triglycerides, HDL and LDL.Induction of diabetes led to significant reduction (p < 0.05) of GSH, catalase, SOD activi-ties and protein content. Feeding on the formulated cake led to their significant increase.Decreased lipid peroxidation, total cholesterol, LDL and triglycerides, and increased con-centration of HDL were also observed on feeding with the cake. These results indicate anantioxidant protective potential of the fibre-enriched cake against diabetic-induced braintoxicity. Thus, it can serve as an adjunct to dietary therapy for diabetes.
  • Item
    Open Access
    Short-Term Feeding of Fibre-Enriched Biscuits: Protective Effect against Hepatotoxicity in Diabetic Rats
    (Hindawi Publishing Corporation, 2015) Erukainure, Ochuko L.; Ebuehi, O.A.T.; Adeboyejo, Folasade O.; Oladunmoye, Olufunmilola O.; Aliyu, Muhammad; Obode, Okukwe C.; Olasehinde, Tosin; Elemo, Gloria N.
    The effects of fibre-enriched biscuit on biomarkers associated with hepatotoxicity in diabetic rats were investigated. Diabetes was induced by single intraperitoneal injection of alloxan monohydrate. Treatment lasted for 14 days after which the rats were sacrificed by cervical dislocation. Blood serumwas analyzed to determine hepatic function enzymes.Theliver was also analyzed to determine hepatic lipid profile and antioxidant enzymes. Induction of diabetes led to elevated levels of ALP, AST, andALT.Thesewere, however, significantly (𝑝 < 0.05) reduced in the fibre-enriched biscuit fed (treated) group.There was no significant difference in the serum bilirubin and total protein levels of the studied groups. Reduced albumin level was observed in the diabetic group; this was further lowered on feeding with fibre-enriched biscuits. Induction of diabetes led to increased hepatic level of cholesterol, triglyceride (TG), low density lipoprotein (LDL), and lipid peroxidation and decreased activities of glutathione (GSH), catalase (CAT), and superoxide dismutase (SOD) and HDL level. These were significantly (𝑝 < 0.05) reversed on feeding with fibre-enriched biscuit. This study portrays the protective effect of fibre-enriched biscuit on increased oxidative stress and hyperlipidemia in hepatic tissues of alloxan-induced diabetic rats.