Haematology and Blood Transfusion- Scholarly Publications

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Browsing Haematology and Blood Transfusion- Scholarly Publications by Author "Adediran, A.A"

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    Open Access
    The Pattern of Leukaemias among Adults in Jos, North Central Nigeria
    (World Journal of Blood, 2017) Damulak, D.O; Egesie, O.J; Jatau, E.D; Ogbenna, A.A; Adediran, A.A
    Introduction: Leukaemias are haemopoietic malignancies classified into acute and chronic. Each of these two main groups is further divided into lymphoid or myeloid leukaemia depending on the cell of origin. Acute leukaemias are common in childhood while the chronic entities dominate the adult life. Aim: This study aimed to determine the pattern of leukaemia cases seen in our setting. Methods: All leukaemia cases seen in the Jos University Teaching Hospital, (JUTH), Jos: North Central Nigeria, from the year 2001 to 2016 were studied. Sociodemographic clinical and laboratory data of the patients were obtained from their case files. Data were analyzed using epi info statistical software. Results: Two hundred and thirty one (231) adults were diagnosed of leukaemia over the study period, 120 (51.95%) males and 48.05% females, aged 18 and 85 years (mean 44.0 ± 17.2). Distribution leukaemia cases based on patient’s age; showed peaks at age 30, 50 70 years. The lowest annual leukaemia capture were the years 2001 and 2010 while the highest rate of diagnosis was in 2014. The chronic and acute were respectively diagnosed in 64.1% and 35.9% of studied subjects. The frequency of individual cases was; CLL (32.5%), CML (31.6%), AML (19.0%) and ALL (16.9%). Acute myeloblastic, lymphoblastic and chronic myelocytic leukaemia showed overall increase with increasing patient’s age over twelve years. The rate of diagnosis of chronic lymphocytic leukaemia however tended to decline from a recorded peak in 2013. Leakaemia in adults was highest in the age group 20-40 years, followed by aged 40-60, 60-80, 18-20 years and least in 80-100 years respectively. Conclusion: Acute leukaemias may be commoner in adults below 40 years while the chronic disorders are commoner in those above 40 years with the age of 30, 50 and 70 years at increased risk.
  • Item
    Open Access
    Serum ferritin levels in adults with sicklecell disease in Lagos, Nigeria
    (Journal of Blood Medicine. Dove Medical Press Ltd., 2013-05-21) Akinbami, A.A; Dosunmu, A.O; Adediran, A.A; Oshinaike, O.O; Osunkalu, V.O; Ajibola, S.O; Arogundade, O.M
    Background: Serum ferritin is considered to be one of the most important tools in the measurement of iron balance in steady-state sickle cell disease. Increased gastrointestinal absorption of iron has been reported in sickle cell disease because of the associated chronic hemolysis, and it is also thought that repeated red cell transfusion consequent to chronic hemolysis and anemia causes excessive iron levels. The aim of this study was to determine overall and gender-specific mean ferritin levels in patients with steady-state sickle cell disease in order to establish the prevalence of iron deficiency and overload.Methods: This was a cross-sectional study in homozygous patients with sickle cell disease attending the sickle cell clinic at Lagos State University Teaching Hospital, Ikeja. A 5 mL blood sample was collected in plain bottles from consenting participants during steady-state periods. The serum was separated and analyzed for ferritin by enzyme-linked immunosorbent assay. Another 5 mL sample was collected for a full blood count, done on the same day of collection, to determine red blood cell indices, ie, mean cell volume, mean cell hemoglobin concentration, and mean corpuscular hemoglobin concentration. The Pearson Chi-square test was used for statistical analysis. The differences were considered to be statistically significant when P was ,0.05.Results: In total, 103 patients were recruited for this study and comprised 58 women (56.40%) and 45 men (43.70%). The overall mean ferritin concentration was 93.72 ± 92.24 ng/mL. The mean ferritin concentration in the women was 92.00 ± 88.07 ng/mL and in men was 96.41 ± 99.80 ng/mL. Only eight (7.76%) of the 103 patients had a serum ferritin level , 15 ng/mL, while two subjects (1.94%) had a serum a ferritin level . 300 ng/mL. Ninety-three subjects (90.29%) had serum ferritin within the normal reference range of 15–300 ng/mL.Conclusion: In this study, 90% of subjects with sickle cell disease had normal iron stores; serum ferritin was higher in men than in women, and iron deficiency was more common than overload in the disease.