Anatomic and Molecular Pathology- Scholarly Publications

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Derivation of a List of Priority Antibodies from the Analysis of a Cohort of Cases sent from Nigeria for External Consultation
(Annals of Tropical Pathology, 2017) Igbokwe, U.O.; Olusina, D. B.; Odubanjo, M. O.; Anunobi, C. C.; Akinde, O. R.; Badmos, K. B.; Abdulkareem, F. B.; Banjo, A. A. F.
Introduction: The major obstacle to developing sustainable services in a resource-limited setting, which hitherto has not had routine availability of diagnostic immunohistochemistry (IHC), is choosing from a large array of over 200 antibodies that are currently in use in the Western world. Materials and Methods: By critically analyzing the use of diagnostic IHC in a cohort of 360 cases sent for consultation from Nigeria to the UK between January 2014 and May 2016, we have derived a list of antibodies that could meet over 85% of current diagnostic IHC needs in Nigeria. Results: From our analysis, a starter list of only two antibodies could immediately meet over 30% of the IHC needs. Having mastered this starter list, the service could move to the next step by adding 23 other antibodies which could meet another 85% of diagnostic IHC needs. Conclusions: Testing with these 25 antibodies can be done at least twice weekly to address the 3 areas mentioned above and greatly increase the chances of success in establishing a sustainable service. We recommend this list to the various groups working with diagnostic IHC in Nigeria and look forward to reports of their efforts.