Department of Medical Microbiology and parasitology

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Browsing Department of Medical Microbiology and parasitology by Author "Adenuga, A."

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    Open Access
    Prevalence of in-use contamination of intravenous infusion in the paediatric wards of lagos university teaching hospital
    (1992) Ogunsola, F.T.; Rotimi, V.O.; Adenuga, A.
    The prevalence of in-use contamination of intravenous fluids on four paedatric wards (D1-D3 and the children emergency wards) was studied between January and June, 1990. A total of 118 in-use and 20 unused (controls) infusion fluids were studied. Contamination levels were high with 40 out of the 118 (33.3%) infusions contaminated while all the 20 control fluids were consistently sterile. The most isolated organisms were Corynebacterium xerosis and Bacillus subtils which from 24 out of 40 (60%) contaminated infusions, Gram-negative bacilli such as Klebsiella aeroqenes, Aerugina and Proteus mirabilis made up the remaining 40% (16 out of 40). Fourteen out of 16 (87.5%) of gram-negative isolates were isolated from ward D1 (Neonatal ward for neonates born outside the hospital). Contributory factors to the high contamination rates were found to be associated with duration of continuous infusion, use of burrettes and ward D1. On the other hand, additives did significantly correlate with contamination rates.
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    Open Access
    Significance of antibiotics resistance amongst clinical bacterial isolates in Lagos
    (1994) Rotimi, V.O.; Onyenefa, P.I.; Banjo, T.O.; Ogunsola, F.T.; Adenuga, A.
    In vitro susceptibility of several strains or six different species or clinical facultative pathogens Involved nosocomial Infections In our hospital was Investigated by a series of disc diffusion, broth dilution and chequerboard titration testing. With disc diffusion method all the test strains, except Streptococcus pyogenes, were resistant to penicillin 46% of the Klebsiellaaerogenes and 73% of the Pseudomonasstarins were generally resistant to cefotax line. The minimum inhibit of y concentration (MIC) of the antibiotics correlated well with the results or the disc diffusion tests. Synergistic effects were demonstrated by various combinations of gentamlein, ampicilin, clindamyclin, coiistin, cefoxitin, and ceftriazone against resistant strains of S. aureus, Pseudomonas aeruginosa, Escherichia coli and Klebsiella aerogens. Against S. aureus the effect of gentamicin/CLindamyein demonstrated indifference. The need for stringent caution is strongly advocated in the selection of combination therapy for serious infections caused by some hospital bacterial strains particularly in aeutecare units. The clinical microbiologist should be consulted at all times during the precoss of selection of an appropriate combined therapy for expert guidance.