Significance of antibiotics resistance amongst clinical bacterial isolates in Lagos
In vitro susceptibility of several strains or six different species or clinical facultative pathogens Involved nosocomial Infections In our hospital was Investigated by a series of disc diffusion, broth dilution and chequerboard titration testing. With disc diffusion method all the test strains, except Streptococcus pyogenes, were resistant to penicillin 46% of the Klebsiellaaerogenes and 73% of the Pseudomonasstarins were generally resistant to cefotax line. The minimum inhibit of y concentration (MIC) of the antibiotics correlated well with the results or the disc diffusion tests. Synergistic effects were demonstrated by various combinations of gentamlein, ampicilin, clindamyclin, coiistin, cefoxitin, and ceftriazone against resistant strains of S. aureus, Pseudomonas aeruginosa, Escherichia coli and Klebsiella aerogens. Against S. aureus the effect of gentamicin/CLindamyein demonstrated indifference. The need for stringent caution is strongly advocated in the selection of combination therapy for serious infections caused by some hospital bacterial strains particularly in aeutecare units. The clinical microbiologist should be consulted at all times during the precoss of selection of an appropriate combined therapy for expert guidance.
Antibiotics , Nosocomial infections , Penicillin resistance , Antibiotic synergism , Facultative pathogens , In vitro susceptibility , Research Subject Categories::MEDICINE::Microbiology, immunology, infectious diseases
Rotimi, V.O, Oyenefa, P.I, Banjo, T.O, Ogunsola, F.T. and Adenuga A. (1994). Significance of antibiotic resistance amongst clinical bacterial isolates in Lagos. W. Afr. J. Med. 13 :81-86.