Department of Anatomic and Molecular Pathology

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Browsing Department of Anatomic and Molecular Pathology by Subject "Carcinoid Tumor, Neuroendocrine Carcinoma, Germ Cell Neoplasms, Orchiectomy, Testicular Neoplasms."

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    Open Access
    Well Differentiated Neuroendocrine Carcinoma of the Testis in a Nigerian Male
    (JOURNAL OF CASE REPORTS, 2015) Abdulkareem, FB; Igbokwe, U; Dawodu, O; Ikeri, NZ; Nnaji, FC; Banjo, AA
    Testicular carcinoids are very rare tumors that account for less than 1% of all testicular neoplasms. We present the first case of a testicular carcinoid tumor in a Nigerian male who had radical orchiectomy on account of a painful left testicular mass. Histology showed a thinly encapsulated lesion composed of sheets of closely packed spindle cells having a uniform ‘salt-and-pepper’ chromatin pattern, and moderate pale cytoplasm within a scant dense fibrocollagenous stroma. Mitoses were scanty and necrosis absent. There was no evidence of an intratubular germ cell tumor. The lesional cells stained positive, on immunohistochemistry, for CD 56, NSE and S100, though they were negative for chromogranin A and synaptophysin. They also showed positivity for AE 1/3 in a para-nuclear dot-like fashion. There was complete negativity for CD 99, CD 117, PLAP and EMA. The cells were weakly positivity for inhibin, while CD 45 marked only a small population of lymphocytes. A diagnosis of a spindle cell type carcinoid tumour/well differentiated neuroendocrine carcinoma was made. The presence of a fibrous capsule suggested a primary testicular lesion and subsequent abdomino-pelvic CT scan showed no intra-abdominal primaries. However, investigations to rule out a focus from the lungs are yet to be done.