Clinical Pharmacy and Biopharmacy- Scholarly Publications

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Browsing Clinical Pharmacy and Biopharmacy- Scholarly Publications by Subject "adherence"

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    Open Access
    Adolescents and Young Adults knowledge, adherence and experiences while on antiretroviral therapy in a tertiary hospital in Lagos, Nigeria: a Mixed-Method Study
    (SAGE, 2021) Aderemi-Williams, R.I.; Razaq, A.R.; Abah, I.O.; Opanuga, O.O.; Akanmu, A.S.
    In Nigeria, there is a paucity of data on knowledge and experiences of adolescents and young adults (AYAs) with HIV and ART, as well as their challenges maintaining optimal adherence. A mixed-method study was carried out between August and September 2018 among AYAs attending Lagos University Teaching Hospital, Nigeria. Data collection was via AYAs’ hospital records, standardized questionnaires, and in-depth interviews (IDIs). The 4-day ACTG tool was used to measure adherence. Collected data were analyzed descriptively. Assessment of 34 AYAs comprising 18 (52.9%) males with 28 (82.4%) students revealed an overall knowledge score about ART and its effect of 73.6%. Twenty-five (73.5%) had poor knowledge of the development of resistant strains of HIV due to non-adherence recorded. Optimal adherence (≥95%) was recorded in 20 (58.8%) AYAs. IDI produced 4 themes: (i) reasons for non-adherence, (ii) ensuring optimal adherence, (iii) Social support systems and disclosure, and (iv) stigmatization. Our study provided formative data and revealed areas for intervention to improve knowledge and adherence to ART.
  • Item
    Open Access
    Prescribers’ Adherence to World Health Organisation Antimalarial Treatment Guideline in a University Medical Centre in Lagos, Nigeria An Intervention Study
    (Nigeria Quarterly journal of Hospital Medicine, 2018) Aderemi-Williams, R.I.; Akanmu, A.C.
    Background: In Nigeria, presumptive treatment had been the norm. In 2010, WHO guideline advocated use of artemether based combination therapy and positive parasitological test. Objective: Evaluation of prescribers' adherence to WHO malaria treatment guideline and standard prescribing indicators. Methods: All prescriptions and laboratory records of malaria parasitological tests within the three months pre- and three months post-intervention study period were used. Face-to-face and provision of educational information leaflets intervention was done for the prescribers. Data was analysed using Statistical Package for Social Sciences Systems (SPSS) software version 20.0. Chi square statistical analysis test employed to determine the effect of intervention at p≤0.05 level of significance. Results: Most (81.7%) patients were adult. Most prescribed antimalarial pre- and post- intervention were Artemether + lumefantrin (71.6% and 59.0%). Only 24.1% and 32.6% patients underwent parasitological testing for malaria pre- and postintervention respectively. Prescriptions contained average of 3.83±1.28 drugs/prescription, 22.84% antibiotics, .76% generic prescription and 7.2% injections. Conclusion: More effective educational interventions for prescribers to stop presumptive treatment of malaria needs to be developed.