Department Of Chemistry

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Browsing Department Of Chemistry by Subject "2-aminophenol"

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    Open Access
    Synthesis and Antimicrobial Activity of Schiff Bases derived from substituted Salicyladehyde with 2-aminophenol and 2-aminothiophenol
    (Journal of Scientific Research and Development, 2013-01) Fasina, T.M.; Ejiah, F.N.; Dueke-Eze, C.U.; Idika, N.
    Schiff bases of substituted salicylaldehydes namely 5-bromosalicylaldehyde and 5-nitrosalicyladehyde with 2- aminophenol and 2-aminothiophenol have been synthesized and characterized by IR, NMR and elemental analysis. All synthesized compounds were screened for their antimicrobial activity against some clinically important bacteria; Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 27853, Staphylococcus aureus ATCC25923, Enterococcus feacalis ATCC 29212 by Agar ditch method using N,N’-dimethylformamide (DMF) and 1,4-dioxane as solvents. Activity data shows a higher activity of the compounds in DMF with the bromo substituted imines more potent than the nitro substituted compounds
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    Open Access
    Synthesis and Antimicrobial Activity of Schiff Bases derived from substituted Salicyladehyde with 2-aminophenol and 2-aminothiophenol
    (Journal of Scientific Research and Development, 2013-01) Fashina, T.M.; Ejiah, F.N.; Dueke-Eze, C.U.; Idika, N.
    Schiff bases of substituted salicylaldehydes namely 5-bromosalicylaldehyde and 5-nitrosalicyladehyde with 2- aminophenol and 2-aminothiophenol have been synthesized and characterized by IR, NMR and elemental analysis. All synthesized compounds were screened for their antimicrobial activity against some clinically important bacteria; Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 27853, Staphylococcus aureus ATCC25923, Enterococcus feacalis ATCC 29212 by Agar ditch method using N,N’-dimethylformamide (DMF) and 1,4-dioxane as solvents. Activity data shows a higher activity of the compounds in DMF with the bromo substituted imines more potent than the nitro substituted compound
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    Open Access
    Synthesis, characterization and structure activity relationship of schiff bases derived from 2-Aminophenol and substituted benzaldehydes
    (2017-02-23) Fasina, T.M.; Ejiah, F.N.; Oloba-Whenu, O.A.; Revaprasadu, N.; Familoni, O.B.
    The structure-antibacterial activity of six Schiff bases synthesized from 2-aminophenol and substituted benzaldehydes was studied by relating the effect of substituent groups on antibacterial activity. The study showed that compounds with electron donating methoxy substituent exhibited higher inhibitory activity against the tested microorganisms than compounds bearing an electron withdrawing chloroor nitro substituent. Quantum chemical studies carried out on the compounds using density functional theory calculations (DFT) revealed that the activity of the Schiff bases is related to the electrostatic potential, ionization potential and alignment of the dipole moment with respect to the imine bond.
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    Open Access
    SYNTHESIS, CHARACTERIZATION AND STRUCTURE ACTIVITY RELATIONSHIP OF SCHIFF BASES DERIVED FROM 2-AMINOPHENOL AND SUBSTITUTED BENZALDEHYDES
    (ftstjournal.com, 2017) Fasina, T.M.; Ejiah, F.N.; Oloba-Whenu, O.A.; Revaprasadu, N.; Familoni, O.B.
    The structure-antibacterial activity of six Schiff bases synthesized from 2-aminophenol and substituted benzaldehydes was studied by relating the effect of substituent groups on antibacterial activity. The study showed that compounds with electron donating methoxy substituent exhibited higher inhibitory activity against the tested microorganisms than compounds bearing an electron withdrawing chloroor nitro substituent. Quantum chemical studies carried out on the compounds using density functional theory calculations (DFT) revealed that the activity of the Schiff bases is related to the electrostatic potential, ionization potential and alignment of the dipole moment with respect to the imine bond.