Haematology and Blood Transfusion- Scholarly Publications

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Anti-Inflammatory properties of the fruit of allanblanckia floribunda oliv. (Guttiferae)
(Botany Research International, 2009) Ayoola, GA.; Akpanika, GA.; Awobajo, FO.; Sofidiya, MO.; Osunkalu, VO.; Coker, HAB.; Odugbemi, TO.
The present study aims to investigate the anti-inflammatory properties of the fruits of Allanblackia floribunda Oliv. [Guttiferae]. The fruits are traditionally used in the treatment of anti-inflammatory conditions. The methanolic extracts of the fruits (100-400 mg/kg, p.o) inhibited carrageenan induced paw oedema in rats in a dose dependent manner. At 400 mg/kg A. floribunda(AF) produced an inhibition of 76.9% compared to 64.3% for indomethacin (10 mg/kg). Acetylsalicylic acid(100 mg/kg - ASA) did not show significant activity in the inhibition of the neurogenic phase, butwas more active thanA. floribunda in the inhibition of the inflammatory phase of formalin-induce pain.A. floribunda was not active as an anti-inflammatory agent up to 2 h in the histamine-induced rat paw oedema but a significant reduction in paw size was observed after 2 h. This suggests that AF was more active in the later phase of the inflammatory process. AF also reduced hot plate latency in a dose dependent manner. Hot plate latency of 26.8 s was recorded for AF at 400 mg/kg compared to 18.12 s for normal saline and 30.6 s for ASA. LD,, value was determined in Swiss albino mice as 20 g/kg and so can be regarded as relatively safe.