Antioxidant and In-vitro Antidiabetic Activities of Fermented Peels of Citrus x Sinensis (l.) Osbeck (Rutaceae)
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Date
2021-12-24
Authors
Oyawaluja, A. A.
Oiseoghaede, J. O.
Odukoya, O. A.
Kubiat, B. E.
Journal Title
Journal ISSN
Volume Title
Publisher
Sami Publishing Company/Iranian Chemical Science and Technologies Association
Abstract
Introduction: The various parts of Citrus sinensis plant have
been employed over the years for medicinal purposes. As part
of the concept of waste to wealth, the medicinal importance of
the peels was exploited. This study aimed at determining the
antioxidant and in vitro antidiabetic activities of fermented peel
extracts of C. sinensis.
Method: Fermentation of the peels was carried out, and
phytochemical tests were done. DPPH free radical scavenging
activity, anti-lipid peroxidation and Antidiabetic assay method
were performed in vitro using standard procedures.
Results: C. sinensis were rich in polyphenols and reducing
sugars. Radical scavenging assay showed an IC50 of 0.57μg/ml
and 1.60μg/ml for fresh peels and dried peels respectively for
DPPH assay, and 0.67μg/ml (fresh) and 0.72μg/ml (dried) for
anti-lipid peroxidation assay. The α-amylase inhibition assay
showed that the fermented fresh peels and fermented dried
peels had IC50 values of 2.23μg/ml and 2.73μg/ml respectively.
The α-glucosidase assay showed better inhibition by the
extracts. Fermented fresh and dried peels had IC50 values of
0.03μg/ml and 0.03μg/ml respectively.
Conclusion: Fermented fresh peels of C. sinensis expressed
relatively stronger protection in the antioxidant and
antidiabetic assays than the fermented dried peels. This study
revealed that extracts can be considered as an important
addition to the therapeutic management for diabetes.
Description
Scholarly article
Keywords
Fermented Citrus sinensis peels , Alpha amylase and Alpha glucosidase , DPPH , Lipid peroxidation , IC50 , Research Subject Categories::PHARMACY::Pharmacognosy
Citation
Oyawaluja Aminat Asabi, Oiseoghaede Joseph Oisemuzeimen, Odukoya Olukemi Abiodun, and Kubiat Blessing E. (2021). Antioxidant and In-vitro Antidiabetic Activities of Fermented Peels of Citrus x Sinensis (l.) Osbeck (Rutaceae).