The impact of HIV-1 subtypes on virologic and immunologic treatment outcomes at the Lagos University Teaching Hospital: A longitudinal evaluation
Date
2020
Authors
Ogbenna, A.A
Meloni, S
Inzaule, S
Hamers, R.L
Sigaloff, K
Osibogun, A
Adeyemo, T.A
Okonkwo, P
Samuels, J.O
Kanki, P.J
Journal Title
Journal ISSN
Volume Title
Publisher
PLoS ONE
Abstract
HIV is a highly diverse virus with significant genetic variability which may confer biologic differences
that could impact on treatment outcomes.
We studied the association between HIV subtypes and immunologic and virologic outcomes
in a longitudinal cohort of 169 patients on combination antiretroviral therapy. Participants
were followed up for 5 years. Demographic data, CD4 cell count and viral loads (VL) were
extracted from medical records. Whole protease gene and codon 1–300 of the reverse transcriptase
gene were sequenced and analysed.
Sixty-four percent of participants were females with a median age of 35 years. Twelve different subtypes were observed, the commonest being CRF 02_AG (55.0%) and subtypes G (23.1%). All subtypes showed steady rise in CD4 count and there was no difference in proportion who achieved CD4+ cell count rise of ≥100 cells/μL from baseline within 12 months’ post-initiation of ART, or ≥350 cells/μL at 60 months’ post-initiation. Median time to attaining a rise of ≥350 cells/μL was 24 months (6–48 months). The proportion that achieved undetectable VL at month 6 and 12 post-initiation of ART were comparable across subtypes. At end of 5th year, there was no statistical difference in proportion with virologic failure.
No association between HIV subtypes and immunologic or virologic response to therapy was observed, suggesting that current first-line ART may have similar efficacy across subtype predominating in South-West Nigeria.
Description
Scholarly article
Keywords
HIV , Treatment outcomes , Research Subject Categories::MEDICINE
Citation
Ogbenna AA, Meloni S, Inzaule S, Hamers RL, Sigaloff K, Osibogun A, et al. (2020) The impact of HIV-1 subtypes on virologic and immunologic treatment outcomes at the Lagos University Teaching Hospital: A longitudinal evaluation. PLoS ONE 15(8): e0238027. https://doi. org/10.1371/journal.pone.0238027