Now showing 1 - 5 of 29
- ItemOpen AccessDermatoglyphic of Autistic Patients in Lagos, Southwest Nigeria(International Journal of Applied Biological Research, 2011-07-14) Sanyaolu, A.O.; Oremosu, A.A.; Duru, F.I.O.; Noronha, C.C.; Olabiyi, O.; Okanlawon, A.O.Studies of selected traits were undertaken to determine the occurrence of dermatoglyphics in autistics as compared with the normal children in Lagos state. Finger and palm prints were taken from 22 autistic children and 22 normal children. Quantitative and qualitative analysis of the traits, descriptive statistics, t test (p <0.05) and χ² (p<0.001), showed a significant difference in digital pattern types between autistic and normal children, but no significant difference in the total mean ridge count. Deferences in arches were not statistically significant. The total ridge count on both hands of autistic children is higher than in the normal. The atd (axial triradius) angle and a-b (distance between a triradius and b triradius) ridge count are higher in normal than in the autistic children. It was concluded that there is evidence to suggest the presence of definite dermatoglyphic features associated with autistic children compared to normal children.
- ItemOpen AccessWarfarin‐induced vitamin K deficiency affects spermatogenesis in Sprague‐Dawley rats(Andrologia, 2019) Sanyaolu, A.O.; Oremosu, A.A.; Osinubi, A.A.; Vermeer, C.; Daramola, A.O.Text attached
- ItemOpen AccessTherapeutic activities of naringenin on efavirenz-induced sleep-like disorder in the midbrain of white albino mice(2020-07-13) Dosumu, Olufunke; Akang, Edidiong; Faniyan, Oluwatomisin; Akanmu, AlaniObjective(s): Efavirenz, has proven to be effective in suppressing human immunodeficiency virus (HIV) viral load; however, complaints of sleep disorders including hallucination, and insomnia have greatly contributed to non-adherence to antiretroviral therapy. This study aimed at investigating therapeutic activities of naringenin on efavirenz-induced sleep disorder. Materials and Methods: Sixty mice were divided into six groups of control, combination antiretroviral therapy (cART), efavirenz, naringenin, naringenin/efavirenz and naringenin/cART. Efavirenz, cART, and naringenin were administered orally and daily at 15 mg/kg, 24 mg/kg and 50 mg/kg, respectively for 28 days. Post neurobehavioral test, oxidative stress, histology and immunohistochemistry for dopamine were carried out after administration process. Results: Efavirenz (P<0.0001) and cART (P<0.01) significantly increased immobility during open field (P<0.01), escape time in seconds (sec) in Morris water maze (P<0.001) and numbers of head-twitch response (HTR) (P<0.0001). Similarly, there was a significant increase in malondialdehyde (MDA) (P<0.0001) and decreased superoxide dismutase (SOD) (P<0.001) and reduced glutathione (GSH) (P<0.001); however, naringenin-treated groups potentiated anti-oxidant function by reducing oxidative stress (P<0.01). Histological evaluation demonstrated severe neurodegeneration, vacuolization and pyknosis in efavirenz and cART compared to naringenin groups. Dopaminergic neurons using immunohistochemial antibody (tyrosine hydroxylase) staining showed poor immunoreactivity in efavirenz and cART in contrast to naringenin groups. Conclusion: Efavirenz and cART have the potential of inducing sleep disorder possibly due to their capability to trigger inflammation and deplete dopamine level. However, naringenin has proven to be effective in ameliorating these damages.
- ItemOpen AccessTesticular toxicological effects of combination antiretroviral therapy (cART): An x-ray on the therapeutic potential of bioflavonoids(2021-07-10) Dosumu, Olufunke; Akang, Edidiong; Okoko, Ini-ibehe; Olowo, Oluwafunmisho; Oremosu, Ademola; Akanmu, AlaniThe advent of combination antiretroviral therapy (cART) has improved the quality of life of people living with HIV/AIDS, however, the side effects of cART on the testes has been of great concern because of the reproductive desires of these people. This study was designed to determine the modulating and curative roles of bioflavonoids on cART-induced testicular disorders. Thirty-five (35) adult male rats were randomly divided into 7 groups and treated with; 1ml of distilled water; 24mg/kg cART (3TC, 300mg+TDF, 300mg+EFV, 600mg); 1% v/v DMSO; 50mg/kg Naringenin (N), 50mg/kg Quercetin (Q), 50mg/kg of Q and N co administered differently with 24mg/kg cART. There was marked depletion of cells of the spermatogenic series in the seminiferous tubules in animals that received cART, while those that received bioflavonoids showed well-structured seminiferous tubules. cART-only treated group had significantly increased MDA levels as well as significantly reduced SOD and GSH levels when compared with control (p<0.05). Hormonal analysis showed a significant increase in TT and LH in the H/N treated group and H/Q group respectively compared with cART-only group (p<0.05) while a significant decrease was observed in FSH in cART-only and other treated groups (except N and H/Q) compared with control (p<0.05). 3β HSD expression was significantly reduced in the cART-only treated group (p<0.05) compared with control while the co-treatment with quercetin significantly (p<0.05) increased 3β HSD expression. This study demonstrates the curative potential of selected bioflavonoids in mitigating testicular cART-induced effects.
- ItemOpen AccessEffect of D-ribose-L-cysteine on aluminum induced testicular damage in male Sprague-Dawley rats(JBRA Assisted Reproduction, 2017) Falana, B; Adeleke, O; Orenolu, M; Osinubi, A.A; Oyewopo, AObjective: This study investigated the effects of D-ribose and L-cysteine on aluminum-induced testicular damage in male Sprague-Dawley rats. Method: A total number of thirty-five (35) adult male Sprague-Dawley rats were divided into four groups (A- D). Group A (comprised five (5) rats) was designated the Control Group that received Physiological Saline; while groups B, C, and D (comprised ten (10) rats) were given 75 mg/kg, 150 mg/kg and 300 mg/kg of body weight of aluminum chloride respectively for 39 days. At day 40, the aluminum-treated groups were subdivided into sub-groups (B1, C1, D1) comprising of five (5) rats each, and 30 mg/ kg body weight of Riboceine were administered for twenty (20) days. Groups B, C and D remained on the normal dosage of aluminum chloride for three more weeks (59 days). Results: Andrological parameters (Sperm count, motility, morphology and testosterone) in the aluminum- treated Groups B and C showed no significant difference in their mean values when compared with their control counterparts, whereas there was a significant reduction in the andrological parameters in Group D rats when compared with the Control animals. Histoarchitecture of the testes “stain with H&E” of Group A, B and C rats appeared normal while Group D rats showed testicular damages with several abnormal seminiferous tubules with incomplete maturation of germinal cell layers and absence of spermatozoa in their lumen; Leydig cells appear hyperplastic. Group B1, C1 and D1 andrological and histological parameters appeared normal. Conclusion: Riboceine treatment significantly attenuates aluminum-induced testicular toxicity in male Sprague-Dawley in rats.