Effects of methanol extract of Ricinus Communis seed (Linn) on male albino rats
Date
2006
Authors
Raji, Y
Oloyo, AK
Morakinyo, AO
Journal Title
Journal ISSN
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Abstract
Aim: To investigate the effect of methanol extract of Ricinus communis seed (RCE) on male rats reproductive
functions. Methods: Thirty-two male albino rats were divided into four groups. Groups 1, 2 and 3 were gavaged
with 0.2 mL of 2.5 % tween 80 (RCE vehicle; control) or 20 mg/(kg·d) and 40 mg/(kg·d) of RCE, respectively, for
30 days, and group 4 was also gavaged with 40 mg/(kg·d) of RCE, but was allowed a recovery periold of 30 days.
Five untreated female rats were cohabited with male rats in each group from day 25 of RCE treatment for 5 days,
except group 4, where cohabitation began on day 25 of the recovery period. All male rats were sacrificed 24 h after
the experiments. The female rats were laparatomized on day 19 of pregnancy and the number and weight of litters
were recorded. Results: There was a significant decrease (P < 0.01) in the weight of the reproductive organs,
sperm functions and serum levels of testosterone in RCE treated rats. There was disorganization in the cytoarchitecture
of the testes, disruption of the seminiferous tubules and erosion of the germinal epithelium. The number and
weight of litters of rats in groups 2 and 4 decreased significantly (P < 0.05) but no changes were observed in group
3. RCE caused no changes in liver, kidney, heart or body weights in male rats. Conclusion: RCE has a reversible
negative impact on male reproductive functions, which appears to be mediated via gonadal disruption in testosterone
secretion.
Description
Keywords
Ricinus communis , sperm , fertility , testosterone
Citation
Raji Y, Oloyo AK and Morakinyo AO. (2006) Effects of methanol extract of Ricinus Communis seed (Linn) on male albino rats. Asian J. Androl. 8(1): 115-121