Synthesis and Antibacterial Activity of N,N- Diethylamide Bearing Benzenesulfonamide Derivatives
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Date
2013-01-25
Authors
Ajani, O.O.
Familoni, O.B.
Echeme, J.O.
Wu, Feipeng
Sujiang, Z.
Journal Title
Journal ISSN
Volume Title
Publisher
eprints.covenantuniversity.edu.ng
Abstract
Sulfonamides are known to represent a class of medicinally important compounds which are extensively used as antibacterial agents. Hence, a series of new N,N-diethyl amide bearing sulfonamides (2a-k) were synthesized via amidation of easily prepared benzenesulfonamide precursors (1a-k). The chemical structures of all synthesized compounds were substantiated using spectroscopic means such as IR, Mass spectra and 1H-NMR as well as analytical data. The antimicrobial activity of these compounds along with streptomycin, was investigated on Escherichia coli and Staphylococcus aureus. The results showed that this skeletal framework exhibited marked potency as antibacterial
agents. The most active antibacterial agent against both targeted organisms was N,Ndiethyl-1-(phenylsulfonyl) piperidine-2-carboxamide (2b).
Description
Staff publications
Keywords
Research Subject Categories::NATURAL SCIENCES::Chemistry::Organic chemistry::Organic synthesis , 2-(Phenylsulfonamido) acetic acid , inhibition zone , N,N-diethylamide , antibacterial study , streptomycin
Citation
Ajani, O. O.[Et...al] (2013). Synthesis and Antibacterial Activity of N, N-Diethylamide Bearing Benzenesulfonamide Derivatives. American Chemical Science Journal, Vol.3(1), 34-49.