SYNTHESIS, CHARACTERIZATION AND STRUCTURE ACTIVITY RELATIONSHIP OF SCHIFF BASES DERIVED FROM 2-AMINOPHENOL AND SUBSTITUTED BENZALDEHYDES
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Date
2017-02-23
Authors
Fasina, T.M.
Ejiah, F.N.
Oloba-whenu, O.A.
Revaprasadu, N.
Familoni, O.B.
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Abstract
The structure-antibacterial activity of six Schiff bases synthesized from 2-aminophenol and substituted
benzaldehydes was studied by relating the effect of substituent groups on antibacterial activity. The study showed
that compounds with electron donating methoxy substituent exhibited higher inhibitory activity against the tested
microorganisms than compounds bearing an electron withdrawing chloroor nitro substituent. Quantum chemical
studies carried out on the compounds using density functional theory calculations (DFT) revealed that the activity
of the Schiff bases is related to the electrostatic potential, ionization potential and alignment of the dipole moment
with respect to the imine bond
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Keywords
Research Subject Categories::NATURAL SCIENCES::Chemistry::Inorganic chemistry , 2-aminophenol, antibacterial activity, schiff bases, quantum chemical studies
Citation
Fasina, T. M., Ejiah, F., Oloba-Whenu, O. A., Revaprasadu, N., & Familoni, O. B.(2017), SYNTHESIS, CHARACTERIZATION AND STRUCTURE ACTIVITY RELATIONSHIP OF SCHIFF BASES DERIVED FROM 2-AMINOPHENOL AND SUBSTITUTED BENZALDEHYDES,FUW trends in science & technology Journal, 2(1)252-256