Coagulation profile in normal full-term neonate in the first week of life in Lagos-Nigeria
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Date
2016
Authors
Garba, N
Ogbenna, A.A
Adediran, A
Fajolu, I.B.
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Abstract
Normal reference values of haemostatic profile are frequently needed to assist in diagnosis and management of
bleeding disorders. Because of the anatomical and physiological differences between neonates and adults, it is
essential to know the reference range of coagulation profile in neonates in the first week of life. The aim of this study
is to establish a normal reference range for coagulation profile in normal full-term neonates in the first week of life
in Lagos-Nigeria. This is a cross-sectional study carried out among normal full-term neonates born in Lagos Island
Maternity Hospital and Lagos University Teaching Hospital. Neonates’ demographic data were documented.
Citrated plasma was collected and tested for Prothrombin Time (PT), Partial Thromboplastin Time with Kaolin
(PTTK) and Thrombin Time (TT) using Coatron M2 Coagulation Analyzer (TECO GmbH in Germany). Reference
values were established for neonates in the 1st week of life by using the formula of Mean ± 2 Standard Deviation
(SD) that is at 95% confidence level. Comparative analysis was carried out between the mean values of neonates
and adults established mean values. The Mean ± Standard Deviation of PT, PTTK and TT at the first week of life
were 13.41 ± 1.33 seconds, 43.38 ± 6.75 seconds and 24.01 ± 3.03 seconds respectively. Using the formula of Mean
± 2SD, the reference ranges of PT, PTTK and TT were 10.7-16.07seconds, 29.88-56.88 seconds and 17.95-30.07
seconds respectively. Statistically significant difference was observed when mean values of PT, PTTK and TT of
neonates at the 1st week of life were compared with adults established values done in the country and elsewhere in
the world (p-value < 0.05). This research provides a reference range of PT, PTTK and TT for the management of
neonates in the 1st week of life in Lagos, Nigeria. It indicates that reference values of PT, PTTK and TT in neonates
during the 1st week of life are different from that of adults as described in literature. Therefore we cannot use adult
reference values of PT, PTTK and TT to manage neonates during the 1st week of life.
Description
Staff publications
Keywords
Reference values , Full-term neonates , Prothrombin time , Partial thromboplastin time with kaolin , Thrombin time. , Research Subject Categories::MEDICINE
Citation
Garba N, Ogbenna A. A, Adediran A, Fajolu IB. Coagulation profile in normal full-term neonate in the first week of life in Lagos-Nigeria. International Journal of Medical Research & Health Sciences, 2016, 5, 3:44-48