Hypoglycaemic and Biochemical Properties of Cnestis Ferruginea
Date
2010-05
Authors
Adisa, R.A.
Choudhary, M.I.
Adewoye, E.O.
Olorunsogo, O.O.
Journal Title
Journal ISSN
Volume Title
Publisher
African Journal of Traditional, Complementary and Alternative Medicines
Abstract
Increasing incidences of diabetes in Africa has prompted the search for safe and readily available alternative
herbal remedies for the treatment of diabetes mellitus. Cnestis ferruginea was extracted with methanol and
ethylacetate and the extracts obtained were tested for hypoglycaemic activities in streptozotocin (STZ)–induced
diabetic rats and mice. The extracts (250mg/kg body weight) were administered orally for 10 consecutive days to
STZ-induced diabetic rats while a single dose (250mg/kg body weight) of the extracts were administered to STZinduced
diabetic mice. Fasting blood glucose (FBG) levels were determined in the two groups of animals after
extract administration. There was significant reduction in FBG (P< 0.005) by MCF and ECF within 4 hrs of extract
administration in a time- dependent manner. Furthermore, administration of MCF and ECF for 10 days significantly
lowered FBG in STZ diabetic rats (P<0.005) by 74% and 68%, respectively, whereas, glibenclamide - a standard
antidiabetic drug reduced FBG by 60%. The levels of serum creatinine, urea, triglyceride, total cholesterol, total
protein and level of lipid peroxidation were also evaluated. The extracts reduced significantly (P<0.005) the elevated
levels of serum ALT and AST in diabetic treated rats. Similarly, both extracts significantly lowered (P<0.005) the
levels of serum creatinine, urea, total cholesterol, triglyceride and thiobarbituric acid reactive species (TBARS).
These results suggest that Cnestis ferruginea leaves contain a highly potent hypoglycaemic principle and could be a
potential source for isolation of new orally active antihyperglycaemic compounds for attenuating secondary
complications of diabetes such as atherosclerosis, liver and renal dysfunction
Description
Staff publications
Keywords
Research Subject Categories::NATURAL SCIENCES::Chemistry::Biochemistry , Diabetes Mellitus , Cnestis ferruginea , Lipid peroxidation , alanine aminotransferase , aspartate aminotransferase , Hypoglycaemia
Citation
Adisa, R.A., Choudhary, M.I., Adewoye, E.O., & Olorunsogo, O.O. (2010). Hypoglycaemic and Biochemical Properties of Cnestis Ferruginea. African Journal of Traditional, Complementary and Alternative Medicines, Vol. 7. 185-94. 10.4314.