Prevalence of Chlamydophilia Pneumonia antibodies in women with Pre-Eclampsia in Lagos, Nigeria

Awoleke, J.O ; Ajayi, G.O ; Adegbola, O (2012)

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BACKGROUND: The precise aetiology of pre-eclampsia has remained unknown. It is still a major contributor to maternal and perinatal morbidity and mortality. OBJECTIVE: To determine the relationship between preeclampsia and immunoglobulin G (IgG) antibodies to Chlamydophila pneumoniae. METHODS: One hundred and eleven parturients in a tertiary hospital in Lagos, Nigeria comprising 49 women with preeclampsia and 62 women without pre-eclampsia were studied.Peripheral blood was obtained for Chlamydophila pneumoniae antibodies which were measured using a solidphase enzyme-linked immunosorbent assay and maternal diastolic blood pressure, perinatal morbidity and mortality were also assessed. RESULTS: The cases (N = 49) and controls (N = 62) were evenly matched with respect to age and parity. The women with pre-eclampsia delivered at significantly lower gestational ages than those with normotensive gestations. 66.7% of all the subjects were seropositive for Chlamydophila pneumoniae antibodies. 38 out of the 49 cases (77.6%) were positive for the Chlamydophila pneumoniae antibodies compared with 36 out of the 62 controls (58.1%) [p<0.05].Higher antibody titres were found in parous women with a previous history of preeclampsia compared with those without a previous history (p = 0.0308).However, there was no significant association between antibody titres and pregnancy outcome (p > 0.05). CONCLUSION: Results from this study suggest a link between Chlamydophila pneumoniae IgG antibodies and pre-eclampsia. Further prospective studies with larger sizes are needed to verify this association and identify therapeutic options that will effectively prevent the onset or progression of preeclampsia.