A study of some mechanisms of experimental salt-induced hypertension in Rats

Obiefuna, P.C (1992-01)

Degree of Doctor of Philosophy in the Department of Physiology

Thesis

A relationship between high blood pressure and dietary salt intake has been postulated for over a century. Dietary salt ingestion is now known to positively correlate with arterial blood pressure in man and experimental animals. The underlying mechanisms are however not clear. This study examined vascular smooth muscle activity in a sprague-Dawey rat model of salt-induced hypertension.