Urine methylmalonic acid levels in HIV-infected adults with peripheral neuropathy

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dc.contributor.authorAdediran, A.
dc.contributor.authorAdeyemo, T.
dc.contributor.authorAkinbami, A.
dc.contributor.authorOsunkalu, V.
dc.contributor.authorAkanmu, A.
dc.date.accessioned2020-11-17T09:23:43Z
dc.date.available2020-11-17T09:23:43Z
dc.date.issued2013-05-05
dc.descriptionStaff Publicationsen_US
dc.description.abstractBackground:Cobalamin deficiency and peripheral neuropathy (PN) are commonly seen in HIV-infected adults. The level of urine methylmalonicacid (UMMA), a reliableindicator of tissue cobalamin status, was determined in HIV infected subjects with and without PN to establish this association.Methods:One hundred and ninety-eight (198) consenting HIV infected subjects with and without PN were recruited for the study. UMMA level was determined by CationExchange High Performance Liquid Chromatography (HPLC) with Ultraviolet detector in 165 subjects. Simple proportions of patients with raised UMMA (defined as value> 3.4 mg in 24hr) were determined for each arm.Results:Among the 198 subjects studied, 146 had PNand52 had no PN. From the 165 subjects whose UMMA was studied, raised UMMA was found in 76.6% (36 of 47) of subjects with no PN as compared with 53.4% (63 of 118) of those with PN (p=0.018).Conclusion:Cobalamin deficiency (measured by UMMA level) even though common in HIV infected subjects, may not be the cause of peripheral neuropathyin these subjects.en_US
dc.identifier.citationAdediran, A., Adeyemo, T., Akinbami, A., Osunkalu, V., Akanmu Alani (2013). Urine methylmalonic acid levels in HIV-infected adults with peripheral neuropathy. Caspian Journal of internal medicine, 4(3):707-711.en_US
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/8942
dc.language.isoenen_US
dc.publisherCaspian Journal of internal medicineen_US
dc.relation.ispartofseriesCaspian Journal of internal medicine;Vol.4(3)
dc.subjectPeripheral Neuropathyen_US
dc.subjectCobalamin deficiencyen_US
dc.subjectUrine methylmalonicacid (UMMA)en_US
dc.subjectHIV infectionen_US
dc.subjectResearch Subject Categories::MEDICINEen_US
dc.titleUrine methylmalonic acid levels in HIV-infected adults with peripheral neuropathyen_US
dc.typeArticleen_US
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