Estimating the Risk of ABO Hemolytic Disease of the Newborn in Lagos

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Akanmu, A.S.
Oyedeji, O.A.
Adeyemo, T.A.
Ogbenna, A.A.
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Journal of Blood Transfusion
Background: ABO hemolytic disease of the newborn is the most common hemolytic consequence of maternofetal blood group incompatibility restricted mostly to non-group O babies of group O mothers with immune anti-A or anti-B antibodies. Aim: We estimated the risk of ABO HDN with view to determining need for routine screening for ABO incompatibility between mother and fetus. Materials and Methods: Prevalence of ABO blood group phenotypes in blood donor s at the donor clinic of the Lagos University Teaching Hospital and arithmetic methods were used to determine population prevalence of ABO genes. We then estimated proportion of pregnancies of group O mothers carrying a non-group-O baby and the risk that maternofetal ABO incompatibility will cause clinical ABOHDN. Results: Blood from 9138 donors was ABO typed. 54.3%, 23%, 19.4%, and 3.3% were blood groups O, A, B, and AB, respectively. Calculated gene frequencies were 0.1416, 0.1209, and 0.7375 for A, B, and O genes, respectively. It was estimated that 14.3% of deliveries will result in a blood groupO woman giving birth to a child who is non-group-O. Approximately 4.3% of deliveries are likely to suffer ABO HDN with 2.7% prone to suffer from moderately severe to severe hemolysis.
Staff publications
new born babies , Hemolysis , Incompatibility , Antibodies , Blood groups , Research Subject Categories::MEDICINE
Alani, A.S., Oyedeji, O.A., Adeyemo, T.A. and Ogbenna AA. (2015). Estimating the Risk of ABO Hemolytic Disease of the Newborn in Lagos. Journal of Blood Transfusion, Volume 2015, ID 560738; pg 1-5.