Estimating the Risk of ABO Hemolytic Disease of the Newborn in Lagos

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dc.contributor.authorAkanmu, A.S.
dc.contributor.authorOyedeji, O.A.
dc.contributor.authorAdeyemo, T.A.
dc.contributor.authorOgbenna, A.A.
dc.date.accessioned2020-01-20T11:46:12Z
dc.date.available2020-01-20T11:46:12Z
dc.date.issued2015-09-03
dc.descriptionStaff publicationsen_US
dc.description.abstractBackground: ABO hemolytic disease of the newborn is the most common hemolytic consequence of maternofetal blood group incompatibility restricted mostly to non-group O babies of group O mothers with immune anti-A or anti-B antibodies. Aim: We estimated the risk of ABO HDN with view to determining need for routine screening for ABO incompatibility between mother and fetus. Materials and Methods: Prevalence of ABO blood group phenotypes in blood donor s at the donor clinic of the Lagos University Teaching Hospital and arithmetic methods were used to determine population prevalence of ABO genes. We then estimated proportion of pregnancies of group O mothers carrying a non-group-O baby and the risk that maternofetal ABO incompatibility will cause clinical ABOHDN. Results: Blood from 9138 donors was ABO typed. 54.3%, 23%, 19.4%, and 3.3% were blood groups O, A, B, and AB, respectively. Calculated gene frequencies were 0.1416, 0.1209, and 0.7375 for A, B, and O genes, respectively. It was estimated that 14.3% of deliveries will result in a blood groupO woman giving birth to a child who is non-group-O. Approximately 4.3% of deliveries are likely to suffer ABO HDN with 2.7% prone to suffer from moderately severe to severe hemolysis.en_US
dc.identifier.citationAlani, A.S., Oyedeji, O.A., Adeyemo, T.A. and Ogbenna AA. (2015). Estimating the Risk of ABO Hemolytic Disease of the Newborn in Lagos. Journal of Blood Transfusion, Volume 2015, ID 560738; pg 1-5.en_US
dc.identifier.otherdoi.org/10.1155/2015/560738.
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/7463
dc.language.isoenen_US
dc.publisherJournal of Blood Transfusionen_US
dc.relation.ispartofseriesJournal of Blood Transfusion;
dc.subjectnew born babiesen_US
dc.subjectHemolysisen_US
dc.subjectIncompatibilityen_US
dc.subjectAntibodiesen_US
dc.subjectBlood groupsen_US
dc.subjectResearch Subject Categories::MEDICINEen_US
dc.titleEstimating the Risk of ABO Hemolytic Disease of the Newborn in Lagosen_US
dc.typeArticleen_US
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