Estimating the Risk of ABO Hemolytic Disease of the Newborn in Lagos

Simple item page
dc.contributor.authorAkanmu, A.S.
dc.contributor.authorOyedeji, O.A.
dc.contributor.authorAdeyemo, T.A.
dc.contributor.authorOgbenna, A.A.
dc.date.accessioned2022-01-31T11:16:24Z
dc.date.available2022-01-31T11:16:24Z
dc.date.issued2015
dc.descriptionScholarly articlesen_US
dc.description.abstractABO hemolytic disease of the newborn is the most common hemolytic consequence of maternofetal blood group incompatibility restricted mostly to non-group-O babies of group O mothers with immune anti-A or anti-B antibodies. Aim. We estimated the risk of ABO HDN with view to determining need for routine screening for ABO incompatibility between mother and fetus. Materials and Methods. Prevalence of ABO blood group phenotypes in blood donors at the donor clinic of the Lagos University Teaching Hospital and arithmetic methods were used to determine population prevalence of ABO genes. We then estimated proportion of pregnancies of group O mothers carrying a non-group-O baby and the risk that maternofetal ABO incompatibility will cause clinical ABO HDN. Results. Blood from 9138 donors was ABO typed. 54.3%, 23%, 19.4%, and 3.3% were blood groups O, A, B, and AB, respectively. Calculated gene frequencies were 0.1416, 0.1209, and 0.7375 for A, B, and O genes, respectively. It was estimated that 14.3% of deliveries will result in a blood group O woman giving birth to a child who is non-group-O. Approximately 4.3% of deliveries are likely to suffer ABO HDN with 2.7% prone to suffer from moderately severe to severe hemolysis.en_US
dc.identifier.citationAkanmu, A.S., Oyedeji, O.A., Adeyemo, T.A. and Ogbenna, A.A. (2015). Estimating the Risk of ABO Hemolytic Disease of the Newborn in Lagos. Journal of Blood Transfusion, 2015, 1-5.en_US
dc.identifier.other10.1155/2015/560738
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/10862
dc.language.isoenen_US
dc.publisherJournal of Blood Transfusionen_US
dc.subjectABO hemolytic diseaseen_US
dc.subjectABO genesen_US
dc.subjectNewbornen_US
dc.subjectAntibodiesen_US
dc.subjectResearch Subject Categories::MEDICINEen_US
dc.titleEstimating the Risk of ABO Hemolytic Disease of the Newborn in Lagosen_US
dc.typeArticleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Estimating_risk_of_ABO_hemolytic...pdf[1].pdf
Size:
278.73 KB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Haematology and Blood Transfusion- Scholarly Publications