Evaluation of Neuroendocrine Dysfunction in the Acute, Subacute and Chronic Phases of Traumatic Brain Injury
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Date
2017
Authors
Ojieh, G.C.
Ebuehi, O.A.T.
Okhiai, O.
Journal Title
Journal ISSN
Volume Title
Publisher
Scientific & Academic Publishing
Abstract
Traumatic Brain Injury (TBI) is a leading cause of premature death and disability worldwide. The greatest
challenge associated with endocrine complications in individuals with TBI is early recognition of the subtle problems and in
particular at what time after trauma the diagnosis should be made. The plasma testosterone and cortisol concentrations of
established mild, moderate and severe TBI Patient were determined especially at the acute, sub-acute, and chronic phases of
the TBI. Ninety six male adults without history of chronic ailment were enrolled in the study. In each case, blood was
collected within 24h in the first instance, and subsequently at 1st week and 6th week of trauma. The plasma testosterone and
cortisol levels were assayed using ELISA. Eighty five of the men with moderate to severe TBI had significantly low mean
testosterone level of 3.8nmol/L (1.10ng /ml), moderate to severe TBI had lowered cortisol levels, while those with mild TBI
had increased concentration in acute phase, but normal concentrations in the subacute and chronic phases of study. The
testosterone and cortisol deficiencies may require replacement to improve recovery and healing from the effects of TBI.
Description
Keywords
Research Subject Categories::NATURAL SCIENCES::Chemistry::Biochemistry , Traumatic brain injury , Testosterone , TBI , Cortisol , Endocrine dysfunction
Citation
Ojieh G. C., Ebuehi O. A. T., Okhiai O. Evaluation of Neuroendocrine Dysfunction in the Acute, Subacute and Chronic Phases of Traumatic Brain Injury. American Journal of Medicine and Medical Sciences 2017, 7(4): 170-173 DOI: 10.5923/j.ajmms.20170704.02.