Evaluation of Neuroendocrine Dysfunction in the Acute, Subacute and Chronic Phases of Traumatic Brain Injury

Simple item page
dc.contributor.authorOjieh, G.C.
dc.contributor.authorEbuehi, O.A.T.
dc.contributor.authorOkhiai, O.
dc.date.accessioned2019-09-27T07:29:09Z
dc.date.available2019-09-27T07:29:09Z
dc.date.issued2017
dc.description.abstractTraumatic Brain Injury (TBI) is a leading cause of premature death and disability worldwide. The greatest challenge associated with endocrine complications in individuals with TBI is early recognition of the subtle problems and in particular at what time after trauma the diagnosis should be made. The plasma testosterone and cortisol concentrations of established mild, moderate and severe TBI Patient were determined especially at the acute, sub-acute, and chronic phases of the TBI. Ninety six male adults without history of chronic ailment were enrolled in the study. In each case, blood was collected within 24h in the first instance, and subsequently at 1st week and 6th week of trauma. The plasma testosterone and cortisol levels were assayed using ELISA. Eighty five of the men with moderate to severe TBI had significantly low mean testosterone level of 3.8nmol/L (1.10ng /ml), moderate to severe TBI had lowered cortisol levels, while those with mild TBI had increased concentration in acute phase, but normal concentrations in the subacute and chronic phases of study. The testosterone and cortisol deficiencies may require replacement to improve recovery and healing from the effects of TBI.en_US
dc.identifier.citationOjieh G. C., Ebuehi O. A. T., Okhiai O. Evaluation of Neuroendocrine Dysfunction in the Acute, Subacute and Chronic Phases of Traumatic Brain Injury. American Journal of Medicine and Medical Sciences 2017, 7(4): 170-173 DOI: 10.5923/j.ajmms.20170704.02.en_US
dc.identifier.issn2165-901X
dc.identifier.issn2165-9036
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/6165
dc.language.isoenen_US
dc.publisherScientific & Academic Publishingen_US
dc.subjectResearch Subject Categories::NATURAL SCIENCES::Chemistry::Biochemistryen_US
dc.subjectTraumatic brain injuryen_US
dc.subjectTestosteroneen_US
dc.subjectTBIen_US
dc.subjectCortisolen_US
dc.subjectEndocrine dysfunctionen_US
dc.titleEvaluation of Neuroendocrine Dysfunction in the Acute, Subacute and Chronic Phases of Traumatic Brain Injuryen_US
dc.typeArticleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
OJIEH PAPER 2017 10.5923.j.ajmms.20170704.02[1].pdf
Size:
165.53 KB
Format:
Adobe Portable Document Format
Description:
Full Text
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Biochemistry-Scholarly Publications