The effects of intrasound therapy on the healing of tendon exposed to alcohol

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dc.contributor.authorAiyegbusi, A.I
dc.contributor.authorDosumu, O.O
dc.contributor.authorSamuel, T.A
dc.contributor.authorAnunobi, C.C
dc.contributor.authorDuru, F.I
dc.contributor.authorAkinfeleye, A
dc.contributor.authorOkafor, U.A
dc.date.accessioned2022-01-28T11:16:32Z
dc.date.available2022-01-28T11:16:32Z
dc.date.issued2015
dc.descriptionScholarly articlesen_US
dc.description.abstractBackground: Functional abnormalities in wound structure has been identified as a potential complication if a patient consumes alcohol prior to injury and studies suggest that even a single incidence of acute ethanol exposure can have adverse effects on the tissue response to trauma. Ethanol ingestion has been shown to result in abnormal and delayed healing 3 weeks after injury. Objective: This study investigated the effects of Low Intensity Intrasound therapy (LITR) given twice daily on the morphology and antioxidant parameters in the healing tendon following an acute injury in rats exposed to prior ethanol consumption. Methods: Fifteen male rats randomized into three groups, all had induced crush injury to the Lt Achilles tendon. Groups 2 and 3 had prior administration of 30% ethanol for six days while Group 1 (Control) had no alcohol and no follow up intervention. Group 2 received no treatment while group 3 had LITR twice daily. LITR was commenced immediately post-injury and was given over the first 6 days. The animals were sacrificed on day 20 post-injury and the tendons excised and processed for histology, antioxidant and malondialdehyde (MDA) assay. Results: The tendons in Group 2 showed disordered and haphazard collagen formation with neutrophilic infiltrates and high tenoblast population 20 days post-injury while the LITR tendons demonstrated dense, organized, parallel collagen deposits with fewer tenoblasts. LITR also significantly improved the antioxidant parameters and lowered the MDA when compared with the tendon of rats that were fed alcohol but received no treatment (p<0.05). Conclusion: LITR reversed the deleterious effect of ethanol on the healing tendon and resulted in near-normal morphology of the healing tendon 20 days post-injuryen_US
dc.identifier.citationAiyegbusi, A.I Dosumu, O.O Samuel, T.A Anunobi, C.C Duru, F.I Akinfeleye, A Okafor, U.A. The effects of intrasound therapy on the healing of tendon exposed to alcohol. Uni of Lagos J of Basic Med Sci. 2015; 3 (1):1-6en_US
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/10833
dc.language.isoenen_US
dc.publisherUniversity of Lagos, Faculty of Basic Medical Sciencesen_US
dc.subjectAlcoholen_US
dc.subjectintrasound therapyen_US
dc.subjecttendon healingen_US
dc.subjecttendon injuryen_US
dc.subjectResearch Subject Categories::MEDICINEen_US
dc.titleThe effects of intrasound therapy on the healing of tendon exposed to alcoholen_US
dc.typeArticleen_US
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