Antinociceptive and antiulcer activities of Pycnanthus angolensis
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Pycnanthus angolensis (Welw) Warb., Myristicaceae, is used in Nigeria folk medicine to treat complaints such as toothache, headache, sore throat, ulcers and wounds. The aim of the study was to investigate the antinociceptive and antiulcer activities of the stem bark extract of Pycnanthus angolensis. Acute tox-icity was conducted with a single oral dose of 5 g/kg. Antinociceptive activity was evaluated in acetic acid-induced writhing, formalin and tail immersion tests in mice while antiulcer activity was evaluated in ethanol and indomethacin-induced models in rats. In acetic acid-induced writhing test, the extract (50, 100 and 150 mg/kg, p.o.), signiﬁcantly reduced the number of writhes (46.75%, 57.28% and 75.69%) respectively, compared to control. The extract signiﬁcantly (p < 0.001) reduced the time spent in licking the hind paw at both phases, in formalin test. In tail immersion test, signiﬁcant antinociceptive effect was only observed with the dose of 150 mg/kg, with peak effect at 90 min (43.38%). There is no signiﬁcant change in the spontaneous locomotor activity of animals in the open ﬁeld. The extract prevented the gas-tric ulceration caused by ethanol and indomethacin treatments compared to control. The results showed that P. angolensis extract possesses antinociceptive and antiulcer activities supporting the traditional use for relieving pain and ulcers.
Pycnanthus angolensis Myristicaceae Ethanolic extract Antinociceptive Antiulcer , Pycnanthus angolensis , Myristicaceae , Ulcers , Research Subject Categories::PHARMACY::Pharmacognosy
Margaret Oluwatoyin Sofidiya and Adepero Olubukola Awolesi (2015). Antinociceptive and antiulcer activities of Pycnanthus angolensis. Revista Brasileira de Farmacognosia (Brazillian Journal of Pharmacognosy) 25, 252-257.