Antinociceptive and antiulcer activities of Pycnanthus angolensis

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dc.contributor.authorSofidiya, M.O.
dc.contributor.authorAwolesi, A.O.
dc.date.accessioned2021-04-15T10:29:36Z
dc.date.available2021-04-15T10:29:36Z
dc.date.issued2015
dc.descriptionScholarly articlesen_US
dc.description.abstractPycnanthus angolensis (Welw) Warb., Myristicaceae, is used in Nigeria folk medicine to treat complaints such as toothache, headache, sore throat, ulcers and wounds. The aim of the study was to investigate the antinociceptive and antiulcer activities of the stem bark extract of Pycnanthus angolensis. Acute tox-icity was conducted with a single oral dose of 5 g/kg. Antinociceptive activity was evaluated in acetic acid-induced writhing, formalin and tail immersion tests in mice while antiulcer activity was evaluated in ethanol and indomethacin-induced models in rats. In acetic acid-induced writhing test, the extract (50, 100 and 150 mg/kg, p.o.), significantly reduced the number of writhes (46.75%, 57.28% and 75.69%) respectively, compared to control. The extract significantly (p < 0.001) reduced the time spent in licking the hind paw at both phases, in formalin test. In tail immersion test, significant antinociceptive effect was only observed with the dose of 150 mg/kg, with peak effect at 90 min (43.38%). There is no significant change in the spontaneous locomotor activity of animals in the open field. The extract prevented the gas-tric ulceration caused by ethanol and indomethacin treatments compared to control. The results showed that P. angolensis extract possesses antinociceptive and antiulcer activities supporting the traditional use for relieving pain and ulcers.en_US
dc.identifier.citationMargaret Oluwatoyin Sofidiya and Adepero Olubukola Awolesi (2015). Antinociceptive and antiulcer activities of Pycnanthus angolensis. Revista Brasileira de Farmacognosia (Brazillian Journal of Pharmacognosy) 25, 252-257.en_US
dc.identifier.issn1981-528X
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/9291
dc.language.isoenen_US
dc.publisherSpingeren_US
dc.relation.ispartofseriesBrazillian Journal of Pharmacognosy;25
dc.subjectPycnanthus angolensis Myristicaceae Ethanolic extract Antinociceptive Antiulceren_US
dc.subjectPycnanthus angolensisen_US
dc.subjectMyristicaceaeen_US
dc.subjectUlcersen_US
dc.subjectResearch Subject Categories::PHARMACY::Pharmacognosyen_US
dc.titleAntinociceptive and antiulcer activities of Pycnanthus angolensisen_US
dc.typeArticleen_US
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