The aqueous root extract of Aristolochia ringens (Vahl.) Aristolochiaceae inhibits chemically induced inflammation in rodents.
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Faculty of Pharmacy, University of Karachi
The potential of the aqueous root extract of Aristolochia ringens (AR) (10-100 mg/kg p.o) to inhibit inflammation induced by phlogistics was evaluated using the carrageenan and egg albumin induced rat paw oedema, formaldehyde induced arthritic inflammation and xylene induced mouse ear oedema models. AR (10-50 mg/kg) dose-dependently decreased rat paw oedema in the carrageenan and egg albumin induced inflammation, producing comparable inhibition of 57.1% and 65.6% to the 57.9% and 63.9% of indomethacin and diclofenac (10 mg/kg p.o) respectively at 50 mg/kg. AR (10-50 mg/kg) also dose dependently inhibited formaldehyde-induced arthritic paw oedema over the 10 day observation period, with a greater inhibition of 50% at 50 mg/kg than the 40.8% inhibition by diclofenac (10 mg/kg i.p). AR (50 mg/kg) also produced greater inhibition of 84.78% than the 65.21% by dexamethasone (1 mg/kg) in xylene-induced ear oedema. Results show that the aqueous root extract of Aristolochia ringens possesses antiinflammatory activity.
Aristolochia ringens , Anti-inflammatory activity , Carrageenan , Prostaglandin , Rodents , Research Subject Categories::PHARMACY::Pharmacognosy
Aigbe Flora Ruth, Adeyemi Olufunmilayo Olaide, Sofidiya Margaret Oluwatoyin (2014). The aqueous root extract of Aristolochia ringens (Vahl.) Aristolochiaceae inhibits chemically induced inflammation in rodents. Pakistan Journal of Pharmaceutical Sciences, 27 (6), 1885-1889.