The aqueous root extract of Aristolochia ringens (Vahl.) Aristolochiaceae inhibits chemically induced inflammation in rodents.

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dc.contributor.authorAigbe, F.R.
dc.contributor.authorAdeyemi, O.O.
dc.contributor.authorSofidiya, M.O.
dc.date.accessioned2021-04-16T12:48:14Z
dc.date.available2021-04-16T12:48:14Z
dc.date.issued2014
dc.descriptionScholarly articlesen_US
dc.description.abstractThe potential of the aqueous root extract of Aristolochia ringens (AR) (10-100 mg/kg p.o) to inhibit inflammation induced by phlogistics was evaluated using the carrageenan and egg albumin induced rat paw oedema, formaldehyde induced arthritic inflammation and xylene induced mouse ear oedema models. AR (10-50 mg/kg) dose-dependently decreased rat paw oedema in the carrageenan and egg albumin induced inflammation, producing comparable inhibition of 57.1% and 65.6% to the 57.9% and 63.9% of indomethacin and diclofenac (10 mg/kg p.o) respectively at 50 mg/kg. AR (10-50 mg/kg) also dose dependently inhibited formaldehyde-induced arthritic paw oedema over the 10 day observation period, with a greater inhibition of 50% at 50 mg/kg than the 40.8% inhibition by diclofenac (10 mg/kg i.p). AR (50 mg/kg) also produced greater inhibition of 84.78% than the 65.21% by dexamethasone (1 mg/kg) in xylene-induced ear oedema. Results show that the aqueous root extract of Aristolochia ringens possesses antiinflammatory activity.en_US
dc.identifier.citationAigbe Flora Ruth, Adeyemi Olufunmilayo Olaide, Sofidiya Margaret Oluwatoyin (2014). The aqueous root extract of Aristolochia ringens (Vahl.) Aristolochiaceae inhibits chemically induced inflammation in rodents. Pakistan Journal of Pharmaceutical Sciences, 27 (6), 1885-1889.en_US
dc.identifier.issn1011-601X
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/9306
dc.language.isoenen_US
dc.publisherFaculty of Pharmacy, University of Karachien_US
dc.relation.ispartofseriesPakistan Journal of Pharmaceutical Sciences;27(6)
dc.subjectAristolochia ringensen_US
dc.subjectAnti-inflammatory activityen_US
dc.subjectCarrageenanen_US
dc.subjectProstaglandinen_US
dc.subjectRodentsen_US
dc.subjectResearch Subject Categories::PHARMACY::Pharmacognosyen_US
dc.titleThe aqueous root extract of Aristolochia ringens (Vahl.) Aristolochiaceae inhibits chemically induced inflammation in rodents.en_US
dc.typeArticleen_US
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