Anti-inflammatory and analgesic activities of the aqueous extract of Acacia karroo stem bark in experimental animal
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Wiley Online Library
The aqueous extract of the stem bark of Acacia karroo Hayne was investigated for its anti-inﬂammatory and analgesic activities in animal models. The extract at 100 and 200 mg/kg reduced signiﬁcantly the formation of oedema induced by carrageenan and histamine. In the acetic acid-induced writhing model, the extract showed a good analgesic effect characterized by a signiﬁcant reduction in the number of writhes with two doses (100 and 200 mg/kg) used when compared to the untreated control group. In the tail immersion test, the extract at the doses used (100 and 200 mg/kg) increased reaction time to pain after 30 min. of oral administration of the extract. Indomethacin at 10 mg/kg served as reference drug in all these tests. The results gave a scientiﬁc basis to the traditional uses of Acacia karroo mainly for wound poultices, eye treatments and cold remedies.
Animal models , Antiinflammatory , Cold remedies , Histamine , Research Subject Categories::PHARMACY::Pharmacognosy
Adeolu A. Adedapo, Margaret O. Sofidiya, Patrick J. Masika, Anthony J. Afolayan (2008). Anti-inflammatory and analgesic activities of the aqueous extract of Acacia karroo stem bark in experimental animal. Basic and Clinical Pharmacology and Toxicology 103, 397- 400.