Anti-inflammatory and analgesic activities of the aqueous extract of Acacia karroo stem bark in experimental animal

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dc.contributor.authorAdedapo, A.A.
dc.contributor.authorSofidiya, M.O.
dc.contributor.authorMasika, P.J.
dc.contributor.authorAfolayan, A.J.
dc.date.accessioned2021-04-27T13:03:23Z
dc.date.available2021-04-27T13:03:23Z
dc.date.issued2008
dc.descriptionScholarly articlesen_US
dc.description.abstractThe aqueous extract of the stem bark of Acacia karroo Hayne was investigated for its anti-inflammatory and analgesic activities in animal models. The extract at 100 and 200 mg/kg reduced significantly the formation of oedema induced by carrageenan and histamine. In the acetic acid-induced writhing model, the extract showed a good analgesic effect characterized by a significant reduction in the number of writhes with two doses (100 and 200 mg/kg) used when compared to the untreated control group. In the tail immersion test, the extract at the doses used (100 and 200 mg/kg) increased reaction time to pain after 30 min. of oral administration of the extract. Indomethacin at 10 mg/kg served as reference drug in all these tests. The results gave a scientific basis to the traditional uses of Acacia karroo mainly for wound poultices, eye treatments and cold remedies.en_US
dc.identifier.citationAdeolu A. Adedapo, Margaret O. Sofidiya, Patrick J. Masika, Anthony J. Afolayan (2008). Anti-inflammatory and analgesic activities of the aqueous extract of Acacia karroo stem bark in experimental animal. Basic and Clinical Pharmacology and Toxicology 103, 397- 400.en_US
dc.identifier.issn1742-7843
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/9377
dc.language.isoenen_US
dc.publisherWiley Online Libraryen_US
dc.relation.ispartofseriesBasic and Clinical Pharmacology and Toxicology;103
dc.subjectAnimal modelsen_US
dc.subjectAntiinflammatoryen_US
dc.subjectCold remediesen_US
dc.subjectHistamineen_US
dc.subjectResearch Subject Categories::PHARMACY::Pharmacognosyen_US
dc.titleAnti-inflammatory and analgesic activities of the aqueous extract of Acacia karroo stem bark in experimental animalen_US
dc.typeArticleen_US
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