Sequence Variability in the NRAMP1 Gene among Indigenous and Exotic Chicken Types

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dc.contributor.authorABAZUH, U.D.
dc.contributor.authorAdekoya, K.O.
dc.contributor.authorOboh, B.O.
dc.date.accessioned2019-07-11T07:34:33Z
dc.date.available2019-07-11T07:34:33Z
dc.date.issued2019-06-18
dc.description.abstractThe natural resistance-associated macrophage protein 1 (NRAMP1) gene in chickens, which exists on chromosome 7, is thought to play a significant role in disease resistance. Variations in this gene have been documented and have played crucial roles in the variations in the resistance and/or susceptibility that is expressed by individuals and different groups of animal species. In this study, the NRAMP1 gene was studied for single nucleotide polymorphism (SNP) variability between indigenous and exotic chicken breeds. The gene was amplified using the polymerase chain reaction (PCR) method and sequenced and analyzed. Six SNPs, both synonymous and non-synonymous (C3700T, G3702C, A3712C, C3714G, C3693G, and G3705T), were detected in the gene in both indigenous and exotic chicken types. One allele form was detected among all the sample animals that were studied. A phylogenetic tree revealed that the indigenous chicken type and the exotic broiler chicken type are genetically similar with respect to this gene. However, the exotic layer chicken type is genetically suggested to be distantly related to both the indigenous and broiler chicken types, indicating that the gene has probably been evolving both within and among different poultry species.en_US
dc.description.sponsorshipUniversitas Indonesiaen_US
dc.identifier.citationAbazuh, Uchenna Desmond, Adekoya, Khalid Olajide and Oboh, Bola Olufunmilayo (2019). Sequence Variability in the NRAMP1 Gene Among Indigenous and Exotic Chicken Types. Makara Journal of Science. 23 (2) : 103 - 108.en_US
dc.identifier.otherdoi: 10.7454/mss.v23i2.11052
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/4296
dc.language.isoenen_US
dc.publisherUniversitas Indonesiaen_US
dc.subjectChickenen_US
dc.subjectNRAMP1 geneen_US
dc.subjectnucleotide variationen_US
dc.subjectphylogenic treeen_US
dc.titleSequence Variability in the NRAMP1 Gene among Indigenous and Exotic Chicken Typesen_US
dc.typeArticleen_US
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