Immunological Profiles of Mice Protected from Chlamydia-induced Infertility by Anti-caspase Treatment

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dc.contributor.authorUkwade, C.E.
dc.contributor.authorEbuehi, O.A.T.
dc.contributor.authorIgietseme, J.U.
dc.contributor.authorOuburg, S.
dc.contributor.authorLand, J.A.
dc.contributor.authorOmosun, Y.
dc.contributor.authorJoseph, K.
dc.contributor.authorPartin, J.
dc.contributor.authorHe, Q.
dc.contributor.authorEko, F.O.
dc.contributor.authorEllerson, D.
dc.contributor.authorBandea, C.
dc.contributor.authorMorre, S.A.
dc.contributor.authorZhong, G.
dc.contributor.authorBlack, C.M.
dc.date.accessioned2019-09-20T15:14:31Z
dc.date.available2019-09-20T15:14:31Z
dc.date.issued2016-04-20
dc.description.abstractThe study is to investigate the effect of anti-caspase treatment on anti-chlamydia immune response in mice. Both the humoral and aspects of cell-mediated immune response against Chlamydia trachomatis were studied. Antibody response was measured using the ELISA technique to identify all common isotypes, and cytokine response was measured using the PCR technique. The antibody levels (IgG, IgG1, IgG2a and IgA) in Z-VAD-FMK treated group were significantly higher than nontreated group. ELISA results [showed a significantly higher amount of antibodies (IgG, IgG1, Ig G2a and IgA)] were produced in the mice that were pre-treated with Z-VAD-FMK before infection with Chlamydia trachomatis compared to mice post treated with Z-VAD-FMK after Chlamydia trachomatis infection. Data of the study indicate that the caspase inhibitor, Z-VAD-FMK did not negatively affect humoral and T cell mediated immune responses against C. trachomatis in mice.en_US
dc.identifier.citationUkwade, C & Ebuehi, Osaretin & Igietseme, Joseph & Ouburg, Sander & Land, J & Omosun, Y & Joseph, K & Partin, James & He, Q & Eko, Francis & Ellerson, D & Bandea, Claudiu & Morré, Servaas & Zhong, G & Black, Carolyn. (2016). Immunological Profiles of Mice Protected from Chlamydia-induced Infertility by Anti-caspase Treatment. British Journal of Medicine and Medical Research. 15. 1-9. 10.9734/BJMMR/2016/23921.en_US
dc.identifier.issn2231-0614
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/5921
dc.language.isoenen_US
dc.publisherSCIENCEDOMAIN internationalen_US
dc.subjectResearch Subject Categories::NATURAL SCIENCES::Chemistry::Biochemistryen_US
dc.subjectChlamydia trachomatisen_US
dc.subjectanti-caspase treatmenten_US
dc.subjectimmune responseen_US
dc.subjectinfertilityen_US
dc.subjectmiceen_US
dc.titleImmunological Profiles of Mice Protected from Chlamydia-induced Infertility by Anti-caspase Treatmenten_US
dc.typeArticleen_US
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