Antimicrobial activities of garcinia kola on oral fusobacterium nucleatum and biofilm

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dc.contributor.authorNwaokorie, F.
dc.contributor.authorCoker, A.
dc.contributor.authorOgunsola, F.T.
dc.contributor.authorGaetti-jardim jr, E.
dc.contributor.authorOyedele, G.
dc.contributor.authorAyanbadejo, P.
dc.contributor.authorAbdurrazaq, T.
dc.contributor.authorUmezudike, A.
dc.date.accessioned2019-12-20T12:03:17Z
dc.date.available2019-12-20T12:03:17Z
dc.date.issued2010-04-04
dc.description.abstractThe extracts from the root, bark and seed of Garcinia kola are currently used in traditional medicine in Nigeria. The aim of this study was to evaluate the inhibitory activity of crude extracts of G. kola on Fusobacterium nucleatum isolated from the oral cavity. Methanol and aqueous extracts were prepared from the seed and the minimal inhibitory concentration was evaluated by the agar dilution method, using a Wilkins-Chalgren agar supplemented with horse blood (5%), hemin (5 µg/ml) and menadione (1 µg/ml). Antimicrobial activity of plant extracts on microbial biofilms was determined in microtiter plates. The seed of G. kola demonstrated significant inhibitory action on F. nucleatum isolates at a concentration of 1.25 and 12.5 mg/ml for amoxicillin resistant strain. It was able to inhibit the microbial biofilm formed by the association of F. nucleatum with Porphyromonas gingivalis ATCC 33277, Aggregatibacter actinomycetemcomitans ATCC 33384 and Prevotella intermedia ATCC 2564 at a concentration of 25 mg/ml. The in-vitro inhibitory effect of G. kola on F. nucleatum population suggests a potential role for its use in oral hygiene.en_US
dc.identifier.citationNwaokorie, F., Coker, A., Ogunsola, F., Gaetti-Jardim Jr, E., Oyedele , G., Ayanbadejo, P., Abdurrazaq, T. and Umezudike, A. (2010). Antimicrobial activities of Garcinia kola on oral Fusobacterium nucleatum and biofilm. African Journal of Microbiology Research ‘4: 509-514.en_US
dc.identifier.issn1996-0808
dc.identifier.urihttps://www.google.com/search?q=Antimicrobial+activities+of+Garcinia+kola+on+oral+Fusobacterium+nucleatum+and+biofilm&oq=Antimicrobial+activities+of+Garcinia+kola+on+oral+Fusobacterium+nucleatum+and+biofilm&aqs=chrome..69i57.708j0j9&sourceid=chrome&ie=UTF-8
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/7226
dc.language.isoenen_US
dc.subjectFusobacterium nucleatumen_US
dc.subjectGarcinia kolaen_US
dc.subjectOral diseaseen_US
dc.subjectNatural medicineen_US
dc.subjectAnaerobic bacteriaen_US
dc.subjectBiofilmen_US
dc.titleAntimicrobial activities of garcinia kola on oral fusobacterium nucleatum and biofilmen_US
dc.typeArticleen_US
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