Association of adiponectin gene (ADIPOQ) polymorphisms with measures of obesity in Nigerian young adults
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Date
2018-01
Authors
Ogundele, O.
Adekoya, K.O.
Osinubi, A.A. A.
Awofala, Awoyemi
Oboh, B.O.
Journal Title
Journal ISSN
Volume Title
Publisher
The Egyptian Journal of Medical Human Genetics _ Elsevier
Abstract
Background: The association of obesity with adiponectin gene has been reported in different populations
with various inconsistencies. Data from Nigeria is very scanty on the association.
Aim: We investigated possible associations of adiponectin gene (ADIPOQ) single nucleotide polymorphisms (SNPs) rs2241766 (+45T>G in exon 2), rs266729 ( 11377C>G in promoter) and rs1501299
(+276G>T in intron 2) with body mass index (BMI), waist circumference (WC) and hip circumference
(HC), in our cross-sectional study.
Subjects and methods: SNPs in ADIPOQ were genotyped in 107 subjects (81 females, 26 males; mean age
22.2 years) by Sequenom MassARRAY. Notably, rs2241766 was removed for not reaching
Hardy-Weinberg equilibrium. BMI was calculated (kg/m2) while WC and HC were measured using standard procedures
Results: Linear regression showed that variant rs1501299 was not associated with BMI, WC or HC but
rs266729 was associated with increased measures of obesity involving BMI (recessive model; beta
coefficient [b], 12.85; 95% confidence interval [CI], 6.47, 19.24, codominant model; GG, b, 13.08; 95%
CI, 6.71, 19.46, GC, b, 1.04; 95% CI, 0.60, 2.68 and log-additive model; b, 2.117; 95% CI, 0.55, 3.68),
WC (recessive model; b, 22.17; 95% CI, 7.11, 37.23 and codominant model; GG, b, 21.857; 95% CI, 6.74,
36.98, GC, b, 1.459; 95% CI, 5.34, 2.43) and HC (recessive model; b, 33.56; 95% CI, 15.41, 51.70, codominant model; GG, b, 34.171; 95% CI, 16.04, 52.30, GC, b, 2.771; 95% CI, 1.79, 7.34 and log-additive model;
b, 5.466; 95% CI, 1.14, 9.80).
Conclusion: This study in young Nigerian adults confirmed previously reported association of SNP
11377C>G with obesity measures in other populations.
Description
Keywords
Obesity , rs2241766 , rs1501299 , rs266729 , Nigeria
Citation
25. Ogundele, E. Olusegun, Adekoya, Khalid O., Osinubi, Abraham A. A., Awofala, A. Awoyemi and Oboh, Bola O. (2018). Association of Adinopectin gene (ADIPOQ) Polymorphisms with measures of Obesity in Nigerian Young Adults. The Egyptian Journal of Medical Human Genetics. 19: 123 - 127