Association of adiponectin gene (ADIPOQ) polymorphisms with measures of obesity in Nigerian young adults

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Ogundele, O.
Adekoya, K.O.
Osinubi, A.A. A.
Awofala, Awoyemi
Oboh, B.O.
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The Egyptian Journal of Medical Human Genetics _ Elsevier
Background: The association of obesity with adiponectin gene has been reported in different populations with various inconsistencies. Data from Nigeria is very scanty on the association. Aim: We investigated possible associations of adiponectin gene (ADIPOQ) single nucleotide polymorphisms (SNPs) rs2241766 (+45T>G in exon 2), rs266729 ( 11377C>G in promoter) and rs1501299 (+276G>T in intron 2) with body mass index (BMI), waist circumference (WC) and hip circumference (HC), in our cross-sectional study. Subjects and methods: SNPs in ADIPOQ were genotyped in 107 subjects (81 females, 26 males; mean age 22.2 years) by Sequenom MassARRAY. Notably, rs2241766 was removed for not reaching Hardy-Weinberg equilibrium. BMI was calculated (kg/m2) while WC and HC were measured using standard procedures Results: Linear regression showed that variant rs1501299 was not associated with BMI, WC or HC but rs266729 was associated with increased measures of obesity involving BMI (recessive model; beta coefficient [b], 12.85; 95% confidence interval [CI], 6.47, 19.24, codominant model; GG, b, 13.08; 95% CI, 6.71, 19.46, GC, b, 1.04; 95% CI, 0.60, 2.68 and log-additive model; b, 2.117; 95% CI, 0.55, 3.68), WC (recessive model; b, 22.17; 95% CI, 7.11, 37.23 and codominant model; GG, b, 21.857; 95% CI, 6.74, 36.98, GC, b, 1.459; 95% CI, 5.34, 2.43) and HC (recessive model; b, 33.56; 95% CI, 15.41, 51.70, codominant model; GG, b, 34.171; 95% CI, 16.04, 52.30, GC, b, 2.771; 95% CI, 1.79, 7.34 and log-additive model; b, 5.466; 95% CI, 1.14, 9.80). Conclusion: This study in young Nigerian adults confirmed previously reported association of SNP 11377C>G with obesity measures in other populations.
Obesity , rs2241766 , rs1501299 , rs266729 , Nigeria
25. Ogundele, E. Olusegun, Adekoya, Khalid O., Osinubi, Abraham A. A., Awofala, A. Awoyemi and Oboh, Bola O. (2018). Association of Adinopectin gene (ADIPOQ) Polymorphisms with measures of Obesity in Nigerian Young Adults. The Egyptian Journal of Medical Human Genetics. 19: 123 - 127