Association of adiponectin gene (ADIPOQ) polymorphisms with measures of obesity in Nigerian young adults

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dc.contributor.authorOgundele, O.
dc.contributor.authorAdekoya, K.O.
dc.contributor.authorOsinubi, A.A. A.
dc.contributor.authorAwofala, Awoyemi
dc.contributor.authorOboh, B.O.
dc.date.accessioned2019-01-14T12:08:51Z
dc.date.available2019-01-14T12:08:51Z
dc.date.issued2018-01
dc.description.abstractBackground: The association of obesity with adiponectin gene has been reported in different populations with various inconsistencies. Data from Nigeria is very scanty on the association. Aim: We investigated possible associations of adiponectin gene (ADIPOQ) single nucleotide polymorphisms (SNPs) rs2241766 (+45T>G in exon 2), rs266729 ( 11377C>G in promoter) and rs1501299 (+276G>T in intron 2) with body mass index (BMI), waist circumference (WC) and hip circumference (HC), in our cross-sectional study. Subjects and methods: SNPs in ADIPOQ were genotyped in 107 subjects (81 females, 26 males; mean age 22.2 years) by Sequenom MassARRAY. Notably, rs2241766 was removed for not reaching Hardy-Weinberg equilibrium. BMI was calculated (kg/m2) while WC and HC were measured using standard procedures Results: Linear regression showed that variant rs1501299 was not associated with BMI, WC or HC but rs266729 was associated with increased measures of obesity involving BMI (recessive model; beta coefficient [b], 12.85; 95% confidence interval [CI], 6.47, 19.24, codominant model; GG, b, 13.08; 95% CI, 6.71, 19.46, GC, b, 1.04; 95% CI, 0.60, 2.68 and log-additive model; b, 2.117; 95% CI, 0.55, 3.68), WC (recessive model; b, 22.17; 95% CI, 7.11, 37.23 and codominant model; GG, b, 21.857; 95% CI, 6.74, 36.98, GC, b, 1.459; 95% CI, 5.34, 2.43) and HC (recessive model; b, 33.56; 95% CI, 15.41, 51.70, codominant model; GG, b, 34.171; 95% CI, 16.04, 52.30, GC, b, 2.771; 95% CI, 1.79, 7.34 and log-additive model; b, 5.466; 95% CI, 1.14, 9.80). Conclusion: This study in young Nigerian adults confirmed previously reported association of SNP 11377C>G with obesity measures in other populations.en_US
dc.description.sponsorshipAin Shams University, Egypt. Production and Hosting by Elsevier B.V.en_US
dc.identifier.citation25. Ogundele, E. Olusegun, Adekoya, Khalid O., Osinubi, Abraham A. A., Awofala, A. Awoyemi and Oboh, Bola O. (2018). Association of Adinopectin gene (ADIPOQ) Polymorphisms with measures of Obesity in Nigerian Young Adults. The Egyptian Journal of Medical Human Genetics. 19: 123 - 127en_US
dc.identifier.otherhttp:dx.doi.org/10.1016/j.ejmhg.2017.08.005
dc.identifier.urihttp://ir.unilag.edu.ng:8080/handle/123456789/3501
dc.language.isoenen_US
dc.publisherThe Egyptian Journal of Medical Human Genetics _ Elsevieren_US
dc.subjectObesityen_US
dc.subjectrs2241766en_US
dc.subjectrs1501299en_US
dc.subjectrs266729en_US
dc.subjectNigeriaen_US
dc.titleAssociation of adiponectin gene (ADIPOQ) polymorphisms with measures of obesity in Nigerian young adultsen_US
dc.typeArticleen_US
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