Extended longitudinal analysis of arterial pressure and heart rate control in unanaesthetised rats with type 1 diabetes

Simple item page
dc.contributor.authorAnigbogu, C. N.
dc.contributor.authorSpeakman, R.O
dc.contributor.authorSilcox, D.L.
dc.contributor.authorBrown, L.V.
dc.contributor.authorBrown, D.R.
dc.contributor.authorGong, M.C.
dc.contributor.authorPatwardhan, A.R.
dc.contributor.authorReynolds, R.L.
dc.contributor.authorKarounos, D.G.
dc.contributor.authorBurgess, D.E.
dc.contributor.authorBaldridge, B.R.
dc.contributor.authorRandall, D.C.
dc.date.accessioned2019-10-04T14:23:37Z
dc.date.available2019-10-04T14:23:37Z
dc.date.issued2012
dc.descriptionStaff publicationsen_US
dc.description.abstractAbstract We recorded arterial pressure (BP) and heart rate (HR) in type-1 diabetic rats vs. controls for > 6 months. Diabetic rats (DIAB) were maintained on insulin from the day glucose >250 mg/dl (“Day 0”). Weight was similar between groups until ~ 3 weeks before Day 0 when the weight in DIAB transiently lagged the controls (CONT); this difference was maintained throughout the study, but both groups otherwise gained weight in parallel. Plasma glucose attained 371 ± 109 (SD) mg/dl by day 1 in DIAB. Mean BP was similar across groups, and declined through the initial 4–6 months in both the CONT (at − 0.06 ± 0.04 mm Hg/day) and in the DIAB (at − 0.14 ± 0.21 mm Hg/day; NS vs. CONT). HR in the CONT (Month 1: 341 ± 13 bpm) exceeded DIAB (325 ± 25 bpm) through ~ 6 months after Day 0, and also decreased progressively over this period in CONT (− 0.19 ± 0.14 bpm/day) and DIAB (− 0.29 ± 0.23 bpm/day; NS vs. CONT) before leveling. The BP power within 0.35–0.45 Hz changed during the 90 min before vs. after the transition from dark to light, and light to dark; there were no between group differences. The slope of the log–log linear portion of the BP power spectrum between 1.0/h and 1/min was similar across groups, and increased in both from month 1 to month 6. Regulatory mechanisms maintain similar profiles in BP and HR in diabetic vs. control animals through the initial half year of the disease.en_US
dc.identifier.citationAnigbogu, C.N. [Et...al] (2012). Extended longitudinal analysis of arterial pressure and heart rate control in unanaesthetised rats with type 1 diabetes. Autonomic Neuroscience: Basic and Clinical 170 (1):20 – 29. doi:10.1016/j.autneu.201206006.en_US
dc.identifier.otherdoi:10.1016/j.autneu.2012.06.006
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/6255
dc.language.isoenen_US
dc.publisherElsevier B.V.en_US
dc.subjectCardiovascular systemen_US
dc.subjectAutonomic nervousen_US
dc.subjectWeight gainen_US
dc.subjectPlasma glucoseen_US
dc.subjectResearch Subject Categories::MEDICINEen_US
dc.titleExtended longitudinal analysis of arterial pressure and heart rate control in unanaesthetised rats with type 1 diabetesen_US
dc.typeArticleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Gally proof July 3 2012 AUTNEU_1430[1].pdf
Size:
1.53 MB
Format:
Adobe Portable Document Format
Description:
Main article
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Physiology- Scholarly Publications