Extended longitudinal analysis of arterial pressure and heart rate control in unanaesthetised rats with type 1 diabetes
dc.contributor.author | Anigbogu, C. N. | |
dc.contributor.author | Speakman, R.O | |
dc.contributor.author | Silcox, D.L. | |
dc.contributor.author | Brown, L.V. | |
dc.contributor.author | Brown, D.R. | |
dc.contributor.author | Gong, M.C. | |
dc.contributor.author | Patwardhan, A.R. | |
dc.contributor.author | Reynolds, R.L. | |
dc.contributor.author | Karounos, D.G. | |
dc.contributor.author | Burgess, D.E. | |
dc.contributor.author | Baldridge, B.R. | |
dc.contributor.author | Randall, D.C. | |
dc.date.accessioned | 2019-10-04T14:23:37Z | |
dc.date.available | 2019-10-04T14:23:37Z | |
dc.date.issued | 2012 | |
dc.description | Staff publications | en_US |
dc.description.abstract | Abstract We recorded arterial pressure (BP) and heart rate (HR) in type-1 diabetic rats vs. controls for > 6 months. Diabetic rats (DIAB) were maintained on insulin from the day glucose >250 mg/dl (“Day 0”). Weight was similar between groups until ~ 3 weeks before Day 0 when the weight in DIAB transiently lagged the controls (CONT); this difference was maintained throughout the study, but both groups otherwise gained weight in parallel. Plasma glucose attained 371 ± 109 (SD) mg/dl by day 1 in DIAB. Mean BP was similar across groups, and declined through the initial 4–6 months in both the CONT (at − 0.06 ± 0.04 mm Hg/day) and in the DIAB (at − 0.14 ± 0.21 mm Hg/day; NS vs. CONT). HR in the CONT (Month 1: 341 ± 13 bpm) exceeded DIAB (325 ± 25 bpm) through ~ 6 months after Day 0, and also decreased progressively over this period in CONT (− 0.19 ± 0.14 bpm/day) and DIAB (− 0.29 ± 0.23 bpm/day; NS vs. CONT) before leveling. The BP power within 0.35–0.45 Hz changed during the 90 min before vs. after the transition from dark to light, and light to dark; there were no between group differences. The slope of the log–log linear portion of the BP power spectrum between 1.0/h and 1/min was similar across groups, and increased in both from month 1 to month 6. Regulatory mechanisms maintain similar profiles in BP and HR in diabetic vs. control animals through the initial half year of the disease. | en_US |
dc.identifier.citation | Anigbogu, C.N. [Et...al] (2012). Extended longitudinal analysis of arterial pressure and heart rate control in unanaesthetised rats with type 1 diabetes. Autonomic Neuroscience: Basic and Clinical 170 (1):20 – 29. doi:10.1016/j.autneu.201206006. | en_US |
dc.identifier.other | doi:10.1016/j.autneu.2012.06.006 | |
dc.identifier.uri | https://ir.unilag.edu.ng/handle/123456789/6255 | |
dc.language.iso | en | en_US |
dc.publisher | Elsevier B.V. | en_US |
dc.subject | Cardiovascular system | en_US |
dc.subject | Autonomic nervous | en_US |
dc.subject | Weight gain | en_US |
dc.subject | Plasma glucose | en_US |
dc.subject | Research Subject Categories::MEDICINE | en_US |
dc.title | Extended longitudinal analysis of arterial pressure and heart rate control in unanaesthetised rats with type 1 diabetes | en_US |
dc.type | Article | en_US |
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