Extended longitudinal analysis of arterial pressure and heart rate control in unanaesthetised rats with type 1 diabetes
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Date
2012
Authors
Anigbogu, C. N.
Speakman, R.O
Silcox, D.L.
Brown, L.V.
Brown, D.R.
Gong, M.C.
Patwardhan, A.R.
Reynolds, R.L.
Karounos, D.G.
Burgess, D.E.
Journal Title
Journal ISSN
Volume Title
Publisher
Elsevier B.V.
Abstract
Abstract
We recorded arterial pressure (BP) and heart rate (HR) in type-1 diabetic rats vs. controls for > 6 months. Diabetic rats (DIAB) were maintained on insulin from the day glucose >250 mg/dl (“Day 0”). Weight was similar between groups until ~ 3 weeks before Day 0 when the weight in DIAB transiently lagged the controls (CONT); this difference was maintained throughout the study, but both groups otherwise gained weight in parallel. Plasma glucose attained 371 ± 109 (SD) mg/dl by day 1 in DIAB. Mean BP was similar across groups, and declined through the initial 4–6 months in both the CONT (at − 0.06 ± 0.04 mm Hg/day) and in the DIAB (at − 0.14 ± 0.21 mm Hg/day; NS vs. CONT). HR in the CONT (Month 1: 341 ± 13 bpm) exceeded DIAB (325 ± 25 bpm) through ~ 6 months after Day 0, and also decreased progressively over this period in CONT (− 0.19 ± 0.14 bpm/day) and DIAB (− 0.29 ± 0.23 bpm/day; NS vs. CONT) before leveling. The BP power within 0.35–0.45 Hz changed during the 90 min before vs. after the transition from dark to light, and light to dark; there were no between group differences. The slope of the log–log linear portion of the BP power spectrum between 1.0/h and 1/min was similar across groups, and increased in both from month 1 to month 6. Regulatory mechanisms maintain similar profiles in BP and HR in diabetic vs. control animals through the initial half year of the disease.
Description
Staff publications
Keywords
Cardiovascular system , Autonomic nervous , Weight gain , Plasma glucose , Research Subject Categories::MEDICINE
Citation
Anigbogu, C.N. [Et...al] (2012). Extended longitudinal analysis of arterial pressure and heart rate control in unanaesthetised rats with type 1 diabetes. Autonomic Neuroscience: Basic and Clinical 170 (1):20 – 29. doi:10.1016/j.autneu.201206006.