A comparative study of serum ferritin levels among unfit and fit blood donors

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dc.contributor.authorOlowoselu, OF
dc.contributor.authorUche, F
dc.contributor.authorOyedeji, O
dc.contributor.authorOtokiti, OE
dc.contributor.authorAyanshina, OA
dc.contributor.authorAkinbami, A
dc.contributor.authorOsunkalu, V
dc.date.accessioned2020-11-09T08:14:57Z
dc.date.available2020-11-09T08:14:57Z
dc.date.issued2019-02-24
dc.descriptionStaff Publicationsen_US
dc.description.abstractBackground: Cheap methodologies are being utilized by low‑resource countries to determine blood donors’ fitness. Important hematological biomarkers might have to be evaluated to enhance the use of these methods. Aims: The study evaluated the pattern of serum ferritin in 18–24 fit and unfit prospective blood donors (PDBs) and the prevalence of iron store deficiency. Settings and Design: This study was a cross‑sectional, study which was conducted at the blood donor clinic of the Lagos University Teaching Hospital. Materials and Methods: Blood samples were collected by venipuncture into sodium‑ethylenediaminetetraacetic acid and plain bottles. The latter was centrifuged and used for ferritin determination via human ferritin enzyme‑linked immunosorbent assay test kit, while the former was used for red cell indices analysis using an autoanalyzer. Statistical Analysis: Data were analyzed using SPSS version 20, values were presented as mean ± standard deviation, and P ≤ 0.05 was considered statistically significant. Results: A total of 263 PDB were recruited into the study consisting of 210 (79%) males and 53 (21%) females, with a mean age of 32.88 ± 8.22. Only 110 (41.8%) of the participants were considered fit, while 153 (58.2%) were unfit using copper sulfate specific gravity. There was no statistically significant difference (P = 0.301) in the mean level of serum ferritin in unfit blood donors (74.5 ± 90.8 µg/L) compared to that of the fit blood donors (61.5 ± 54.5 µg/L). The prevalence of iron store depletion among blood donors in Lagos state was 11.8% (31 of 263) with a higher proportion (7.6%) occurring among unfit donors. However, low levels of serum ferritin (<15 µg/L) were significantly associated with the occurrence of anemia (hemoglobin < 12.5 g/gl) among unit donors (19%; P = 0.05). Conclusion: Although serum ferritin depletion appears to be higher in the unfit blood donors, the use of serum ferritin as an index for the screening and determination of PDBs’ fitness requires further evaluation.en_US
dc.identifier.citationOlowoselu OF, Uche E, Oyedeji O, Otokiti OE, Ayanshina OA, Akinbami A, et al. A comparative study of serum ferritin levels among unfit and fit blood donors. Niger Med J 2019;60:312-6.en_US
dc.identifier.other10.4103/nmj.NMJ_48_19
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/8883
dc.language.isoenen_US
dc.publisherNigerian Medical Journalen_US
dc.subjectBlood donorsen_US
dc.subjectCopper Sulphateen_US
dc.subjectSpecfic gravity methoden_US
dc.subjectHemoglobinen_US
dc.subjectSerum ferritinen_US
dc.subjectResearch Subject Categories::MEDICINEen_US
dc.titleA comparative study of serum ferritin levels among unfit and fit blood donorsen_US
dc.typeArticleen_US
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